POLR3H Antibody [Janelia Fluor® 635]

Product Discontinued

POLR3H Antibody [Janelia Fluor® 635] Summary

• Immunogen: Produced in rabbits immunized with E. coli-derived Human POLR3H fragment.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: POLR3H
• Purity: Antigen and protein A Affinity-purified

Applications/Dilutions

• Dilutions:
  • Immunocytochemistry/ Immunofluorescence
  • Immunohistochemistry-Paraffin
• Application Notes: Optimal dilution of this antibody should be experimentally determined.

Packaging, Storage & Formulations

• Storage: Store at 4C in the dark.
• Buffer: 50mM Sodium Borate
• Preservative: 0.05% Sodium Azide
• Purity: Antigen and protein A Affinity-purified

Notes

Sold under license from the Howard Hughes Medical Institute, Janelia Research Campus.

Alternate Names for POLR3H Antibody [Janelia Fluor® 635]

• DNA-directed RNA polymerase III subunit 22.9 kDa polypeptide
• DNA-directed RNA polymerase III subunit H
• DNA-directed RNA polymerase III subunit RPC8
• KIAA1665MGC29654
• MGC111097
• polymerase (RNA) III (DNA directed) polypeptide H (22.9kD)
• RNA nucleotidyltransferase (DNA-directed)
• RNA polymerase III subunit 22.9 kDa subunit
• RNA polymerase III subunit C8
• RNA polymerase III subunit RPC8
• RPC8RPC22.9

Background

DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleosidetriphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as5S rRNA and tRNAs. Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Actsas nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves astemplate for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encodedRNAs (EBERs) induce type I interferon and NF- Kappa-B through the RIG-I pathway

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: POLR3H