PD-ECGF/Thymidine Phosphorylase Antibody (27917) [Alexa Fluor® 647]

• Reactivity: Hu
• Applications: WB
• Clone: 27917
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Alexa Fluor 647

PD-ECGF/Thymidine Phosphorylase Antibody (27917) [Alexa Fluor® 647] Summary

• Immunogen: S. frugiperda insect ovarian cell line Sf 21-derived recombinant human PD-ECGF/Thymidine Phosphorylase
  Ala11-Gln482
  Accession # P19971
• Specificity: Detects human PD-ECGF/Thymidine Phosphorylase in direct ELISAs and Western blots.
• Isotype: IgG1
• Clonality: Monoclonal
• Host: Mouse
• Purity Statement: Protein A or G purified

Applications/Dilutions

• Dilutions:
  • Western Blot

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied
• Buffer: Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for PD-ECGF/Thymidine Phosphorylase Antibody (27917) [Alexa Fluor® 647]

• dThdPase
• EC 2.4.2
• EC 2.4.2.4
• ECGF
• ECGF1
• ECGF1TP
• endothelial cell growth factor 1 (platelet-derived)
• Gliostatin
• hPD-ECGF
• MEDPS1
• MNGIE
• MTDPS1
• PDECGF
• PD-ECGF
• Platelet-derived endothelial cell growth factor
• TdRPase
• Thymidine Phosphorylase
• TPase
• TYMP

Background

PD-ECGF, also known as Thymidine Phosphorylase and Gliostatin, is produced by placenta, platelets, liver, lung, spleen, lymph nodes, and peripheral lymphocytes. It is overexpressed by many tumors in response to chemical or physical stress. PD-ECGF promotes endothelial cell proliferation and chemotaxis and promotes angiogenesis. PD-ECGF is a key enzyme in the pyrimidine nucleoside salvage pathway. It also metabolizes and inactivates chemotherapeutic drugs such as 5‑fluorouracil and its derivatives. The human PD‑ECGF cDNA encodes a 482 amino acid (aa) polypeptide with a 10 aa propeptide. The protein is localized mostly within the producer cells. N-terminal truncation, resulting in proteins lacking 10 aa and 6 aa, has been observed in PD-ECGF purified from platelets and placenta, respectively. In solution, PD-ECGF exists as a non-disulfide linked homodimer.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.