Melatonin Receptor 1B Blocking Peptide

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Product Details

Summary
Reactivity HuSpecies Glossary
Applications IHC, IHC-P

Order Details

Melatonin Receptor 1B Blocking Peptide Summary

Protein/Peptide Type
Blocking Peptide
Gene
MTNR1B

Applications/Dilutions

Application Notes
The peptide can be used for blocking the binding of NLS932 to its target, Melatonin Receptor 1B. To block the specific antibody activity in immunohistochemistry analysis, pre-incubate the antibody with a 10-100X molar excess of peptide for 60 minutes at room temperature. Optimization of the molar ratio of antigen to antibody may be required. Centrifugation of the pre-adsorbed solution prior to addition to the slide may decrease background due to non-specific binding of large antibody-antigen complexes.

Packaging, Storage & Formulations

Storage
Store at -80C. Avoid freeze-thaw cycles.
Buffer
PBS, pH 7.4
Preservative
No Preservative

Alternate Names for Melatonin Receptor 1B Blocking Peptide

  • FGQTL2
  • Mel 1b melatonin receptor
  • Mel1b receptor
  • MEL-1B-R
  • melatonin receptor 1B
  • melatonin receptor MEL1B
  • melatonin receptor type 1B
  • MT2

Background

Melatonin receptor type 1B (MTNR1B) is a member of the G-protein coupled receptor 1 family. This family is responsible for translating external chemical signals across the cell membrane. MTNR1B is one of two high affinity receptors for melatonin, a hormone secreted by the pineal gland. Pertussis toxin sensitive G proteins, that inhibit adenylate cyclase activity, control the MTNR1B receptor. MTNR1B is expressed in the retina, and to a lesser extent the brain and hippocampus. MTNR1B is thought to regulate reproduction, the circadian cycle, and neurological melatonin levels; as well as participate in light dependent function in the retina. Post translational modifications that may affect MTNR1B are disulfide bonds and glycosylation.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Peptides and proteins are guaranteed for 3 months from date of receipt.

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Product General Protocols

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FAQs for Melatonin Receptor 1B Peptide (NLS932PEP). (Showing 1 - 1 of 1 FAQ).

  1. I saw that you have the antibodies for the both receptors of melatonin but not listed with FACS application. I need more information about what is better for my assay.
    • At this time, none of our melatonin receptor antibodies have been tested and validated in Flow. Should you choose to purchase and test one of them, you would qualify for the Innovator's Rewards program. You should take a look at each individual antibody, the clonality, conjugates, immunogen region and all relevant data in order to decide which product would be most suitable for your needs.

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Bioinformatics Tool for Melatonin Receptor 1B Peptide (NLS932PEP)

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Bioinformatics

Gene Symbol MTNR1B