LGI2 Antibody (748914) [Alexa Fluor® 532]

• Reactivity: Hu
• Applications: WB, ICC/IF
• Clone: 748914
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Alexa Fluor 532

LGI2 Antibody (748914) [Alexa Fluor® 532] Summary

• Immunogen: Chinese hamster ovary cell line CHO-derived recombinant human LGI2
  Gln29-Ser276
  Accession # Q8N0V4
• Specificity: Detects human LGI2 in direct ELISAs and Western blots.
• Source: N/A
• Isotype: IgG2b
• Clonality: Monoclonal
• Host: Mouse
• Purity Statement: Protein A or G purified from hybridoma culture supernatant

Applications/Dilutions

• Dilutions:
  • Immunocytochemistry
  • Western Blot

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied
• Buffer: Supplied 0.2 mg/mL in a saline solution containing BSA and Sodium Azide.

Notes

This product is provided under an agreement between Life Technologies Corporation and R&D Systems, Inc, and the manufacture, use, sale or import of this product is subject to one or more US patents and corresponding non-US equivalents, owned by Life Technologies Corporation and its affiliates. The purchase of this product conveys to the buyer the non-transferable right to use the purchased amount of the product and components of the product only in research conducted by the buyer (whether the buyer is an academic or for-profit entity). The sale of this product is expressly conditioned on the buyer not using the product or its components (1) in manufacturing; (2) to provide a service, information, or data to an unaffiliated third party for payment; (3) for therapeutic, diagnostic or prophylactic purposes; (4) to resell, sell, or otherwise transfer this product or its components to any third party, or for any other commercial purpose. Life Technologies Corporation will not assert a claim against the buyer of the infringement of the above patents based on the manufacture, use or sale of a commercial product developed in research by the buyer in which this product or its components was employed, provided that neither this product nor any of its components was used in the manufacture of such product. For information on purchasing a license to this product for purposes other than research, contact Life Technologies Corporation, Cell Analysis Business Unit, Business Development, 29851 Willow Creek Road, Eugene, OR 97402, Tel: (541) 465-8300. Fax: (541) 335-0354.

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for LGI2 Antibody (748914) [Alexa Fluor® 532]

• FLJ10675
• glioma inactivated 2
• KIAA1916MGC126810
• leucine-rich repeat LGI family, member 2
• LGI1-like protein 2
• LGI2
• LGIL2
• MGC126808

Background

LGI2 (leucine-rich, glioma-inactivated 2) is an approximately 100 kDa secreted glycoprotein in the LGI family of LRR (leucine-rich repeat) proteins. LGI2 cDNA encodes a 28 amino acid (aa) signal sequence and a 517 aa mature protein with 5 LRR domains and 7 EAR (epilepsy-associated repeat) domains. It is mainly expressed in various regions of the brain and spinal cord, but mRNA is also found in the heart and placenta. Mutation or deletion of LGI2 is associated with the temporal lobe epilepsy syndrome PEPS (partial epilepsy with pericentral spikes). Within aa 29-276, human LGI2 shares 99% aa sequence identity with mouse and rat LGI2, provided a 23 aa gap and a 32 aa insertion in mouse LGI2 at sites corresponding to human aa 139 and aa 218, respectively, are disregarded.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Uniprot:
  • Q8N0V4(Human)