LGI2 Antibody (748914) [Alexa Fluor® 405]

• Applications: WB, ICC/IF
• Clone: 748914
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Alexa Fluor 405

LGI2 Antibody (748914) [Alexa Fluor® 405] Summary

• Immunogen: Chinese hamster ovary cell line CHO-derived recombinant human LGI2
  Gln29-Ser276
  Accession # Q8N0V4
• Specificity: Detects human LGI2 in direct ELISAs and Western blots.
• Isotype: IgG2b
• Clonality: Monoclonal
• Host: Mouse
• Purity Statement: Protein A or G purified

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied
• Buffer: Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Background

LGI2 (leucine-rich, glioma-inactivated 2) is an approximately 100 kDa secreted glycoprotein in the LGI family of LRR (leucine-rich repeat) proteins. LGI2 cDNA encodes a 28 amino acid (aa) signal sequence and a 517 aa mature protein with 5 LRR domains and 7 EAR (epilepsy-associated repeat) domains. It is mainly expressed in various regions of the brain and spinal cord, but mRNA is also found in the heart and placenta. Mutation or deletion of LGI2 is associated with the temporal lobe epilepsy syndrome PEPS (partial epilepsy with pericentral spikes). Within aa 29-276, human LGI2 shares 99% aa sequence identity with mouse and rat LGI2, provided a 23 aa gap and a 32 aa insertion in mouse LGI2 at sites corresponding to human aa 139 and aa 218, respectively, are disregarded.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.