GRK5 Antibody (691816) [Alexa Fluor® 405]

• Reactivity: Hu
• Applications: ICC/IF
• Clone: 691816
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Alexa Fluor 405

GRK5 Antibody (691816) [Alexa Fluor® 405] Summary

• Immunogen: E. coli-derived recombinant human GRK5
  Pro463-Ser590
  Accession # P34947
• Specificity: Detects human GRK5 in direct ELISAs. In direct ELISAs, 100% cross-reactivity with recombinant human (rh) GRK6 is observed and no cross-reactivity with rhGRK4 is observed.
• Isotype: IgG2a
• Clonality: Monoclonal
• Host: Mouse
• Purity Statement: Protein A or G purified

Applications/Dilutions

• Dilutions:
  • Immunocytochemistry

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied
• Buffer: Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for GRK5 Antibody (691816) [Alexa Fluor® 405]

• EC 2.7.11
• EC 2.7.11.16
• FLJ39780
• G protein-coupled receptor kinase 5
• G protein-coupled receptor kinase GRK5
• GPRK5
• GPRK5FP2025
• GRK5

Background

G protein-coupled receptor kinases (GRKs) are important modulators of G protein-coupled receptor (GPCR) signaling. Receptor phosphorylation by specific GRKs plays a key role in triggering rapid desensitization. The GRK family consists of 7 isoforms that share a central catalytic domain with homology to other serine/threonine kinases. The catalytic domain is flanked by an amino-terminal RGS domain of 183‑188 amino acids and a carboxyl-terminus of variable length. GRK5 is a member of the GRK4 subfamily, and is expressed in a wide variety of tissues.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.