FKBP38 Antibody (391505) [Alexa Fluor® 594]

• Reactivity: Hu, Mu, Rt
• Applications: WB
• Clone: 391505
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Alexa Fluor 594

FKBP38 Antibody (391505) [Alexa Fluor® 594] Summary

• Immunogen: E. coli-derived recombinant human FKBP38
  Met58-Gly382
  Accession # Q14318
• Specificity: Detects endogenous human, mouse and rat FKBP38 in Western blots.
• Isotype: IgG2b
• Clonality: Monoclonal
• Host: Mouse
• Purity Statement: Protein A or G purified

Applications/Dilutions

• Dilutions:
  • Western Blot

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied
• Buffer: Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for FKBP38 Antibody (391505) [Alexa Fluor® 594]

• 38 kDa FK506-binding protein
• EC 5.2.1.8,38 kDa FKBP
• FK506 binding protein 8, 38kDa
• FK506-binding protein 8 (38kD)
• FK506-binding protein 8
• FKBP38
• FKBP-38
• FKBP38PPIase FKBP8
• FKBP8
• FKBP-8
• FKBPr38
• hFKBP38
• peptidyl-prolyl cis-trans isomerase FKBP8
• rotamase

Background

FK506 Binding Proteins (FKBPs) are intracellular receptors for the immuno-suppressive drug FK506. The FKBP/FK506 complex exerts its immunosuppressive effects by inhibiting calcineurin, a calcium- and calmodulin-dependent serine/threonine phosphatase that functions as a critical signaling molecule during T-cell activation. FKBP38, also known as FKBP8, is a 355 to 412 amino acid (aa) protein with an apparent molecular mass of ~60‑64 kDa in SDS-PAGE. FKBP38 binds to and inhibits calcineurin even in the absence of FK506, indicating that FKBP38 is a constitutively active inhibitor of calcineurin. Additionally, FKBP38 co‑immunoprecipitates with Bcl-2 and Bcl-xL, suggesting that FKBP38 may regulate apoptosis by anchoring Bcl‑2 and Bcl‑xL to mitochondrial membranes. Mouse FKBP38 shares 94% and 87% sequence identity with human and rat FKBP38, respectively.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.