CEACAM16 Antibody (2747B) [Alexa Fluor™ Plus 647]

• Reactivity: Hu
• Clone: 2747B
• Clonality: Monoclonal
• Host: Rabbit
• Conjugate: Alexa Fluor Plus 647

CEACAM16 Antibody (2747B) [Alexa Fluor™ Plus 647] Summary

• Specificity: Detects human CEACAM-16 in direct ELISAs.
• Isotype: IgG
• Clonality: Monoclonal
• Host: Rabbit

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied
• Buffer: Supplied 0.2 mg/mL in a saline solution containing BSA and Sodium Azide.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for CEACAM16 Antibody (2747B) [Alexa Fluor™ Plus 647]

• carcinoembryonic antigen-related cell adhesion molecule 16
• CEACAM-16
• CEAL2
• DFNA4B

Background

Carcinoembryonic Antigen-related Cell Adhesion Molecule 16 (CEACAM-16), or CEAL2, is part of the CEA protein family consisting of CEACAMs and the pregnancy‑specific glycoproteins (PSGs). Both CEACAM and PSG molecules have been identified in humans and belong to the much larger glycosylphosphatidylinositol (GPI)-linked immunoglobulin (Ig) superfamily (1, 2). Unique to the CEA family, CEACAM-16 is a secreted molecule lacking a recognizable transmembrane domain or GPI anchor (3). Mature human CEACAM-16 is 405 amino acids (aa), containing 2 IgC2-like domains and 2 IgV-like domains. CEACAM-16 is one of only five conserved CEACAMs among mice, rats, and humans (2). Mature human CEACAM-16 shares 90% and 89% aa identity with mouse and rat CEACAM‑16, respectively. Originally discovered as a biomarker for colorectal cancer (4), CEACAMs have now been associated with numerous intracellular signaling processes including cell adhesion, cell growth, recognition and differentiation, angiogenesis, and apoptosis (5-7). CEACAM-16 is specifically expressed in the inner ear and has been shown to play a critical role in hearing. CEACAM-16 has been identified as a binding partner for alpha tectorin and specific mutations in CEACAM-16 have been linked to autosomal dominant nonsyndromic deafness (ADNSHL) (3, 8).

1. Beauchemin, N. et al. (1999) Exp. Cell Res. 252:243.
2. Zebhauser R. et al. (2005) Genomics 86:566.
3. Zheng, J. et al. (2011) PNAS. 108(10):4218.
4. Gold P. and Freedman S.O. (1965) J Exp Med 122:467.
5. Obrink, B. (1997) Curr Opin Cell Biol 9:616.
6. Horst, A.K. and Wagener, C. (2004) Handb Exp Pharmacol 283.
7. Kuespert K et al. (2006) Curr Opin Cell Biol. 18(5):565.
8. Wang, H. et al. (2015) J Hum Genet. 60(3):119.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.