GSK-3 beta Products

Description

Glycogen synthase kinase 3, or GSK-3, is a serine/threonine, proline-directed kinase involved in a diverse array of signaling pathways, including glycogen synthesis and cellular adhesion, and has been implicated in Alzheimer's disease. Two forms of GSK-3, designated GSK-3alpha and GSK-3beta, have been identified and differ in their subcellular localization. Tau, a microtubule-binding protein which serves to stabilize microtubules in growing axons, is found to be hyper-phosphorylated in paired helical filaments (PHF), the major fibrous component of neurofibrillary lesions associated with Alzheimer's disease. Hyperphosphorylation of Tau is thought to be the critical event leading to the assembly of PHF. Six Tau protein isoforms have been identified, all of which are phosphorylated by GSK-3. This presents the possibility that miscues in GSK-3 signaling contribute to the onset of Alzheimer's disease.

Bioinformatics

Entrez	2932 Human 84027 Rat
Product By Gene ID	2932
Alternate Names	EC 2.7.11 EC 2.7.11.26 glycogen synthase kinase 3 beta glycogen synthase kinase-3 beta GSK3 beta GSK-3 beta GSK3B GSK3beta isoform

Research Areas for GSK-3 beta

Find related products by research area and learn more about each of the different research areas below.

Cancer
Hypoxia
Lipid and Metabolism
Protein Kinase
Signal Transduction
Wnt Signaling Pathway

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