YAP1 Products

Antibodies
YAP1 Antibody (2F12) - Isofor ...
YAP1 Antibody (2F12) - Isoform 5
H00010413-M01
Species: Hu, Mu, Po, Bv, Ca
Applications: WB, ELISA, ICC/IF, IHC, IP, KD
Host: Mouse Monoclonal
Lysates
YAP1 293T Cell Transient Over ...
YAP1 293T Cell Transient Overexpre...
H00010413-T01
Species: Hu
Applications: WB
YAP1 293T Cell Transient Over ...
YAP1 293T Cell Transient Overexpre...
H00010413-T02
Species: Hu
Applications: WB
Proteins
Recombinant Human YAP1 GST (N ...
Recombinant Human YAP1 GST (N-Term...
H00010413-P01
Species: Hu
Applications: WB, ELISA, Func, ICC/IF, MA, AP
Recombinant Human YAP1 GST (N ...
Recombinant Human YAP1 GST (N-Term...
H00010413-Q01
Species: Hu
Applications: WB, ELISA, MA, PAGE, AP
YAP1 Recombinant Protein Anti ...
YAP1 Recombinant Protein Antigen
NBP2-38430PEP
Species: Hu
Applications: AC

Description

The transcriptional coactivator Yes-associated protein (YAP), also known as Yes-associated protein 1 (YAP1), Yes-Associated Protein YAP65 Homolog, Protein Yorkie Homolog and YAP65 has a theoretical molecular weight of 65 kDa. The YAP1 gene encodes the human ortholog of chicken YAP protein which binds to the SH3 domain of the Yes proto-oncogene product. YAP1 shares homology with the WW domain of transcriptional co-activator with PDZ-binding motif (TAZ), which functions as a transcriptional co-activator by binding to the PPXY motif present in transcription factors and is likely involved in protein-protein interaction. YAP has been identified as a core regulatory mechanism that blocks mammalian glial cell proliferation and cellular reprogramming following damage (1).

YAP plays a role in the development and progression of multiple cancers as a transcriptional regulator of the Hippo signaling pathway. YAP1 encodes a nuclear effector of the Hippo signaling pathway which is involved in development, growth, repair, and homeostasis to play a pivotal role in controlling cell growth and organ size and has emerged as a key player in tumor suppression (2,3). Deregulation of the Hippo pathway causes tumor formation and malignancy, with YAP being a key oncogenic driver in liver carcinogenesis (2) and may function as a potential target for cancer treatment (3).

References

1. Rueda, E. M., Hall, B. M., Hill, M. C., Swinton, P. G., Tong, X., Martin, J. F., & Poche, R. A. (2019). The Hippo Pathway Blocks Mammalian Retinal Muller Glial Cell Reprogramming. Cell Rep, 27(6), 1637-1649.e1636. doi:10.1016/j.celrep.2019.04.047

2. Liu, A. M., Xu, M. Z., Chen, J., Poon, R. T., & Luk, J. M. (2010). Targeting YAP and Hippo signaling pathway in liver cancer. Expert Opin Ther Targets, 14(8), 855-868. doi:10.1517/14728222.2010.499361

3.Ye, S., & Eisinger-Mathason, T. S. (2016). Targeting the Hippo pathway: Clinical implications and therapeutics. Pharmacol Res, 103, 270-278. doi:10.1016/j.phrs.2015.11.025

Bioinformatics

Entrez Human
Mouse
Rat
Uniprot Human
Human
Human
Alternate Names
  • 65 kDa Yes-associated protein
  • COB1
  • Protein Yorkie Homolog
  • Transcriptional Coactivator YAP1
  • YAP
  • YAP1-2gamma
  • YAP2
  • YAP2L
  • YAP65
  • YAP65yes-associated protein 2
  • Yes Associated Protein
  • Yes-associated protein 1
  • Yes-associated protein 1, 65kDa
  • yes-associated protein beta
  • yes-associated protein delta
  • Yes-Associated Protein YAP65 Homolog
  • Yes-Associated Protein
  • YKI
  • yorkie homolog

Research Areas for YAP1

Find related products by research area and learn more about each of the different research areas below.

Breast Cancer
Cancer
Chromatin Research
Core ESC-Like Genes
Phospho-Specific
Signal Transduction
Stem Cell Markers
Transcription Factors and Regulators
Tyrosine Kinases