YAP1 Products

Antibodies
YAP1 Antibody (2F12) - Isofor ...
YAP1 Antibody (2F12) - Isoform 5
H00010413-M01
Species: Hu, Mu, Po, Ca
Applications: WB, ELISA, ICC/IF, IHC, IHC-P, IP, KD
Host: Mouse Monoclonal
Lysates
YAP1 Overexpression Lysate (D ...
YAP1 Overexpression Lysate (Denatu...
H00010413-T01
Species: Hu
Applications: WB
YAP1 Overexpression Lysate (D ...
YAP1 Overexpression Lysate (Denatu...
H00010413-T02
Species: Hu
Applications: WB
Proteins
Recombinant Human YAP1 GST (N ...
Recombinant Human YAP1 GST (N-Term...
H00010413-P01
Species: Hu
Applications: WB, ELISA, PA, AP
Recombinant Human YAP1 GST (N ...
Recombinant Human YAP1 GST (N-Term...
H00010413-Q01
Species: Hu
Applications: WB, ELISA, PA, PAGE, AP
YAP1 Recombinant Protein Anti ...
YAP1 Recombinant Protein Antigen
NBP2-62669PEP
Species: Hu
Applications: AC

Description

The transcriptional coactivator Yes-associated protein (YAP), also known as Yes-associated protein 1 (YAP1), Yes-Associated Protein YAP65 Homolog, Protein Yorkie Homolog and YAP65 has a theoretical molecular weight of 65 kDa. The YAP1 gene encodes the human ortholog of chicken YAP protein which binds to the SH3 domain of the Yes proto-oncogene product. YAP1 shares homology with the WW domain of transcriptional co-activator with PDZ-binding motif (TAZ), which functions as a transcriptional co-activator by binding to the PPXY motif present in transcription factors and is likely involved in protein-protein interaction. YAP has been identified as a core regulatory mechanism that blocks mammalian glial cell proliferation and cellular reprogramming following damage (1).

YAP plays a role in the development and progression of multiple cancers as a transcriptional regulator of the Hippo signaling pathway. YAP1 encodes a nuclear effector of the Hippo signaling pathway which is involved in development, growth, repair, and homeostasis to play a pivotal role in controlling cell growth and organ size and has emerged as a key player in tumor suppression (2,3). Deregulation of the Hippo pathway causes tumor formation and malignancy, with YAP being a key oncogenic driver in liver carcinogenesis (2) and may function as a potential target for cancer treatment (3).

References

1. Rueda, E. M., Hall, B. M., Hill, M. C., Swinton, P. G., Tong, X., Martin, J. F., & Poche, R. A. (2019). The Hippo Pathway Blocks Mammalian Retinal Muller Glial Cell Reprogramming. Cell Rep, 27(6), 1637-1649.e1636. doi:10.1016/j.celrep.2019.04.047

2. Liu, A. M., Xu, M. Z., Chen, J., Poon, R. T., & Luk, J. M. (2010). Targeting YAP and Hippo signaling pathway in liver cancer. Expert Opin Ther Targets, 14(8), 855-868. doi:10.1517/14728222.2010.499361

3.Ye, S., & Eisinger-Mathason, T. S. (2016). Targeting the Hippo pathway: Clinical implications and therapeutics. Pharmacol Res, 103, 270-278. doi:10.1016/j.phrs.2015.11.025

Bioinformatics

Entrez Human
Mouse
Rat
Uniprot Human
Human
Human
Product By Gene ID 10413
Alternate Names
  • YAP2L
  • YAP1-2gamma
  • Yes Associated Protein
  • Yes-Associated Protein YAP65 Homolog
  • Transcriptional Coactivator YAP1
  • Yes-Associated Protein
  • Protein Yorkie Homolog
  • YAP65
  • COB1
  • YAP2
  • yorkie homolog
  • YAP
  • yes-associated protein delta
  • 65 kDa Yes-associated protein
  • yes-associated protein beta
  • Yes-associated protein 1, 65kDa
  • YAP65yes-associated protein 2
  • YKI
  • Yes-associated protein 1

Research Areas for YAP1

Find related products by research area and learn more about each of the different research areas below.

Breast Cancer
Cancer
Chromatin Research
Core ESC-Like Genes
Phospho-Specific
Signal Transduction
Stem Cell Markers
Transcription Factors and Regulators
Tyrosine Kinases

Bioinformatics Tool for YAP1

Discover related pathways, diseases and genes to YAP1. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
Vizit™, under license from BioVista Inc.

Related YAP1 Blog Posts

Check out the latest blog posts on YAP1.
YAP1 - a transcription co-activator and the downstream target of Hippo pathway
YAP1 (Yes-associated protein 1) is a  transcriptional co-activator which acts as a major effector of Hippo signaling pathway that regulates organ size/ tissue homeostasis and cell proliferation, and is an established oncogene (1).  Hippo sig...    Read more.
Read more YAP1 related blogs.