Wnt-1 Products

Description

The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It is very conserved in evolution, and the protein encoded by this gene is known to be 98% identical to the mouse Wnt1 protein at the amino acid level. The studies in mouse indicate that the Wnt1 protein functions in the induction of the mesencephalon and cerebellum. This gene was originally considered as a candidate gene for Joubert syndrome, an autosomal recessive disorder with cerebellar hypoplasia as a leading feature. However, further studies suggested that the gene mutations might not have a significant role in Joubert syndrome. This gene is clustered with another family member, WNT10B, in the chromosome 12q13 region. (provided by RefSeq)

Bioinformatics

Entrez	22408 Mouse 7471 Human
Uniprot	NM_005430 Human NP_005421 Human NP_005421.1 Human P04628 Human
Product By Gene ID	7471
Alternate Names	INT1Proto-oncogene Int-1 homolog proto-oncogene Wnt-1 wingless-type MMTV integration site family, member 1 (oncogene INT1) wingless-type MMTV integration site family, member 1

Research Areas for Wnt-1

Find related products by research area and learn more about each of the different research areas below.

Apoptosis
Breast Cancer
Cellular Markers
Stem Cell Signaling Pathway
Wnt Signaling Pathway