WISP-1/CCN4 Products

Description

WISP1 encodes a member of the WNT1 inducible signaling pathway (WISP) protein subfamily, which belongs to the connective tissue growth factor (CTGF) family. WNT1 is a member of a family of cysteine-rich, glycosylated signaling proteins that mediate diverse developmental processes. The CTGF family members are characterized by four conserved cysteine-rich domains: insulin-like growth factor-binding domain, von Willebrand factor type C module, thrombospondin domain and C-terminal cystine knot-like domain. This gene may be downstream in the WNT1 signaling pathway that is relevant to malignant transformation. It is expressed at a high level in fibroblast cells, and overexpressed in colon tumors. The encoded protein binds to decorin and biglycan, two members of a family of small leucine-rich proteoglycans present in the extracellular matrix of connective tissue, and possibly prevents the inhibitory activity of decorin and biglycan in tumor cell proliferation. It also attenuates p53-mediated apoptosis in response to DNA damage through activation of the Akt kinase. It is 83% identical to the mouse protein at the amino acid level. Alternative splicing of this gene generates 2 transcript variants. [provided by RefSeq]

Bioinformatics

Entrez	22402 Mouse 65154 Rat 8840 Human
Uniprot	NM_003882 Human NM_080838 Human NP_003873.1 Human NP_543028 Human NP_543028.1 Human O54775 Mouse O95388 Human WISP1_HUMAN Human
Product By Gene ID	8840
Alternate Names	CCN family member 4 CCN4WISP1tc WISP-1 WISP1c WISP1i WNT1 induced secreted protein 1 WNT1 inducible signaling pathway protein 1 Wnt-1 inducible signaling pathway protein 1 wnt-1 signaling pathway protein 1 Wnt-1-induced secreted protein WNT1-inducible-signaling pathway protein 1

Research Areas for WISP-1/CCN4

Find related products by research area and learn more about each of the different research areas below.

Apoptosis
Cancer
DNA Repair