VE-Cadherin Products

Description

VE-cadherin (cadherin-5) is an endothelial specific adhesion molecule that is essential for the maintenance of endothelial barrier function and angiogenesis. VE-cadherin is linked to the actin cytoskeleton through a number of adaptor proteins including a-, â-, and ã-catenin. Cytoskeletal dynamics and phosphorylation regulate VE-cadherin mediated cell-cell adhesion. The cytosolic C-terminal Src kinase (Csk) binds via its SH2 domain to the phosphorylated tyrosine 658 site of VE-cadherin. This interaction regulates density dependent cell proliferation. Phosphorylation of tyrosine 658 has also been shown to lead to the uncoupling of p120-catenin from the cytoplasmic tail of VE-cadherin. This phosphorylation event is sufficient to maintain cells in a mesenchymal state during the cell invasion phase of angiogenesis.

Bioinformatics

Entrez	1003 Human 12562 Mouse
Uniprot	NM_001795 Human NP_001786 Human P33151 Human P55284 Mouse
Product By Gene ID	1003
Alternate Names	7B4 antigen 7B4 cadherin 5, type 2 (vascular endothelium) cadherin 5, type 2, VE-cadherin (vascular epithelium) cadherin-5 CD144 antigen CD144 endothelial-specific cadherin FLJ17376 Vascular endothelial cadherin VE-cadherin

Research Areas for VE-Cadherin

Find related products by research area and learn more about each of the different research areas below.

Cancer
Cell Cycle and Replication
Cellular Markers
Extracellular Matrix
Phospho-Specific
Plasma Membrane Markers
Signal Transduction

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