Tie-2 Products

Description

TIE2 (tyrosine kinase with Ig and EGF homology domains 2) is expressed almost exclusively in endothelial cells in mice, rats and humans. This receptor possesses a unique extracellular domain containing two immunoglobulin like loops separated by three epidermal growth factor like repeats that are connected to three fibronectin type III like repeats. The ligand for the receptor is Angiopoietin 1. Defects in TIE2 are associated with inherited venous malformations; the TIE2 signaling pathway appears to be critical for endothelial cell smooth muscle cell communication in venous morphogenesis.

Bioinformatics

Entrez	21687 Mouse 7010 Human
Uniprot	AAH35514 Human ABW03349.1 Human NM_000459 Human NP_000450 Human Q02763 Human Q02858 Mouse
Product By Gene ID	7010
Alternate Names	angiopoietin-1 receptor CD202b antigen CD202B EC 2.7.10 EC 2.7.10.1 hTIE2 p140 TEK soluble TIE2 variant 1 soluble TIE2 variant 2 TEK tyrosine kinase, endothelial TIE-2 TIE2CD202b Tunica interna endothelial cell kinase Tyrosine-protein kinase receptor TEK Tyrosine-protein kinase receptor TIE-2 venous malformations, multiple cutaneous and mucosal VMCM VMCM1

Research Areas for Tie-2

Find related products by research area and learn more about each of the different research areas below.

Angiogenesis
Cancer
Phospho-Specific
Protein Kinase

Related Tie-2 Blog Posts

Check out the latest blog posts on Tie-2.

Chemotherapy-induced metastasis: An unexpected foe? By Yoskaly Lazo-Fernandez, PhD IntroductionEvidence has accumulated recently indicating that common cancer therapies might stimulate metastasis in a significant number of cancer patients1. In fact, neoadjuvant che...    Read more.

Read more Tie-2 related blogs.