Hu, Mu, Rt, Po, Bv, Pm, Rb, ShApplications:
WB, IB, ICC/IF, IHC, IHC-Fr, IHC-P, KDHost:
Hu, Mu, Rt, Po, PmApplications:
WB, Flow, ICC/IF, IHC, IHC-P, IPHost:
NOX4 (RENOX) is a renal gp91-phox homolog which functions in the kidney as an oxygen sensor and regulates the synthesis of erythropoietin. This protein is highly expressed at the site of erythropoietin production in the proximal convoluted tubule epithelial cells of the renal cortex.
NOX-4 is also expressed in fetal tissues, placenta, glioblastoma and vascular cells. Like gp91-phox, the enzymatic activity of NOX4 produces superoxide anions. In vascular cells, the addition of angiotensin II increases NOX4 expression, which indicates that NOX4 has a role in vascular oxidative stress response. NOX4 has a role as a redox messenger in the activation of intracellular signaling pathways leading (or contributing) to mitochondriogenesis, cell survival, and differentiation in hematopoietic stem cells. Data suggest that NOX4 provides a novel link between the insulin receptor and the generation of cellular reactive oxygen species that enhances insulin signal transduction.
|Product By Gene ID
- Kidney oxidase-1
- EC 1.6.3
- RENOXEC 1.6.3.-
- KOX-1Renal NAD(P)H-oxidase
- Kidney superoxide-producing NADPH oxidase
- NADPH oxidase 4
Bioinformatics Tool for Nox4
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Related Nox4 Blog Posts
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|NOX4 Antibodies: Don't NOX them until you've tried them
NOX4 is an NADPH oxidase that generates superoxide within the cell. It is primarily found in vascular cells, fibroblasts, and osteoclasts, with abundant expression in the kidney. Unlike its family members NOX1 and NOX2, NOX4 is constitutively active,... Read more.
|NOX4 Antibodies in Diabetic Nephropathy Research
Diabetic nephropathy (DN) is one of the leading complications resulting from chronic diabetes. It manifests as progressive renal failure caused by mesangial cell hyperplasia and fibrosis, and is one of the leading causes of terminal kidney disease (1)... Read more.