Nox4 Products

Antibodies
Nox4 Antibody
Nox4 Antibody
NB110-58851
Species: Hu, Mu, Rt, Po, Pm
Applications: WB, Flow, ICC/IF, IHC, IHC-P, IP
Host: Rabbit Polyclonal
Nox4 Antibody
Nox4 Antibody
NBP2-41293
Species: Hu, Mu, Rt
Applications: WB, ELISA, ICC/IF, IHC, IF
Host: Rabbit Polyclonal
Lysates
Nox4 Overexpression Lysate (N ...
Nox4 Overexpression Lysate (Native)
NBP2-04362
Applications: WB
Proteins
Nox4 Peptide
Nox4 Peptide
NB110-58849PEP
Species: Hu
RNAi
Nox4 RNAi
Nox4 RNAi
H00050507-R01
Species: Hu

Description

NOX4 (RENOX) is a renal gp91-phox homolog which functions in the kidney as an oxygen sensor and regulates the synthesis of erythropoietin. This protein is highly expressed at the site of erythropoietin production in the proximal convoluted tubule epithelial cells of the renal cortex.

NOX-4 is also expressed in fetal tissues, placenta, glioblastoma and vascular cells. Like gp91-phox, the enzymatic activity of NOX4 produces superoxide anions. In vascular cells, the addition of angiotensin II increases NOX4 expression, which indicates that NOX4 has a role in vascular oxidative stress response. NOX4 has a role as a redox messenger in the activation of intracellular signaling pathways leading (or contributing) to mitochondriogenesis, cell survival, and differentiation in hematopoietic stem cells. Data suggest that NOX4 provides a novel link between the insulin receptor and the generation of cellular reactive oxygen species that enhances insulin signal transduction.

Bioinformatics

Uniprot Human
Human
Human
Mouse
Rat
Product By Gene ID 50507
Alternate Names
  • Kidney oxidase-1
  • EC 1.6.3
  • KOX
  • RENOXEC 1.6.3.-
  • KOX-1Renal NAD(P)H-oxidase
  • Kidney superoxide-producing NADPH oxidase
  • NADPH oxidase 4

Research Areas for Nox4

Find related products by research area and learn more about each of the different research areas below.

Cancer
Cell Biology
Diabetes Research
Hypoxia
Lipid and Metabolism
Signal Transduction

Bioinformatics Tool for Nox4

Discover related pathways, diseases and genes to Nox4. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
Vizit™, under license from BioVista Inc.

Related Nox4 Blog Posts

Check out the latest blog posts on Nox4.
NOX4 Antibodies: Don't NOX them until you've tried them
NOX4 is an NADPH oxidase that generates superoxide within the cell. It is primarily found in vascular cells, fibroblasts, and osteoclasts, with abundant expression in the kidney. Unlike its family members NOX1 and NOX2, NOX4 is constitutively active,...    Read more.
NOX4 Antibodies in Diabetic Nephropathy Research
Diabetic nephropathy (DN) is one of the leading complications resulting from chronic diabetes. It manifests as progressive renal failure caused by mesangial cell hyperplasia and fibrosis, and is one of the leading causes of terminal kidney disease (1)...    Read more.
Read more Nox4 related blogs.