Nectin-4/PVRL4 Products

Description

PVRL4, also known as Poliovirus receptor-related protein 4, is a 510 amino acid protein that is 55 kDa, predominantly expressed in placenta and breast carcinoma, is a single-pass type I membrane protein involved in cell adhesion through trans-homophilic and -heterophilic interactions, the latter including specifically interactions with PVRL2/nectin-1, and oes not act as receptor for alpha-herpesvirus entry into cells. Disease research is being performed in relation to this protein and ectodermal dysplasia, syndactyly, ectodermal dysplasia-syndactyly syndrome 1, measles, ovarian cancer, breast carcinoma, lung cancer, and carcinoma. The PVRL4 protein has shown an interaction with PVRL1, MLLT4, PICK1, TIGIT, PARD3, PVRL3, and PVRL2 in Adherens junctions interactions, Nectin/Necl trans heterodimerization, Cell junction organization, Cell-Cell communication, Cell-cell junction organization, Sertoli-Sertoli Cell Junction Dynamics, and Epithelial Adherens Junctions pathways.

Bioinformatics

Entrez	81607 Human
Uniprot	AAH10423.1 Human NM_030916 Human NP_112178 Human Q96NY8 Human
Product By Gene ID	81607
Alternate Names	EDSS1 Ig superfamily receptor LNIR LNIRnectin 4 Nectin-4 nectin-4 poliovirus receptor-related 4 poliovirus receptor-related protein 4 PRR4DKFZp686K05193