Hu, Mu, Rt, Bv, CaApplications:
WB, Flow, ICC/IF, IHC, IHC-PHost:
Hu, Mu, Rt, MkApplications:
WB, ICC/IF, IHC, IHC-PHost:
Hu, Mu, RtApplications:
ICC/IF, IHC, IHC-PHost:
Applications: RNAi, RNAi SP
Stressed mammalian cells up-regulate heme oxygenase 1 (HO-1), which catabolizes heme to biliverdin, carbon monoxide, and free iron. Results provide genetic evidence that up-regulation of HO-1 serves as an adaptive mechanism to protect cells from oxidative damage during stress (1). When cells are injured they release their contents, resulting in a local accumulation of free heme proteins and heme. HO-1 plays a crucial role in the inflammatory process during wound healing (2). TNFalpha accelerates inflammatory responses by down-regulating HO-1 expression in human monocytes. TNF antagonists may block this TNF-dependent suppression of HO-1 expression, resulting in an amelioration of inflammation (3).
Bioinformatics Tool for HO-1/HMOX1/HSP32
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