Glyoxalase II/HAGH Products

Description

HAGH, also known as Hydroxyacylglutathione hydrolase mitochondrial, has a 308 amino acid long isoform that is 34 kDa and located in the mitochondrion matrix and a short 260 amino acid isoform that is 29 kDa and located in the cytoplasm; is classified as a thiolesterase and is responsible for the hydrolysis of S-lactoyl-glutathione to reduced glutathione and D-lactate. Studies are being performed on the relationship of this protein to glyoxalase ii deficiency, breast carcinoma, carcinoma, familial Mediterranean fever, muscular dystrophy, thrombocytosis, neisseria meningitides, hyperglycemia, bladder carcinoma, alzheimer's disease, prostate cancer, hepatitis b, and prostatitis. HAGH protein involvement has been observed with relation to pyruvate metabolism, secondary metabolite metabolism, methylglyoxal degradation, and (R)-lactate from methylglyoxal pathways where it interacts with MYOC, PRDX2, VPS72, SOD1, and DR1.

Bioinformatics

Entrez	3029 Human
Uniprot	NM_005326 Human NP_001035517 Human NP_001035517.1 Human NP_005317 Human Q16775 Human
Product By Gene ID	3029
Alternate Names	EC 3.1.2.6 GLO2hydroxyacyl glutathione hydrolase Glx II GLXII Glyoxalase II HAGH1GLX2 hydroxyacylglutathione hydrolase hydroxyacylglutathione hydrolase, mitochondrial hydroxyacylglutathione hydroxylase

Research Areas for Glyoxalase II/HAGH

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Lipid and Metabolism
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