GFR alpha-3/GDNF R alpha-3 Products

Description

Members of the glial cell line-derived neurotrophic factor (GDNF) family including GDNF and neurturin (NTN) play essential roles in the control of vertebrate neuron survival and differentiation. A new member of the GDNF family was recently identified and designated persephin. Physiological responses to these neurotrophic factors require two receptor subunits, the novel glycosylphosphadidylinositol linked protein GFRa and Ret receptor tyrosine kinase GFRb. Following the findings of GFRa-1 and -2, a novel receptor in GFRa family was identified very recently from human and mouse and designated GFRa-3. GFRa-3 binds persephin, thus, persephin, GFRa-3, and Ret PTK form a complex to transduce persephin signal and to mediate persephin function.

Bioinformatics

Entrez	2676 Human 14587 Mouse 84422 Rat
Uniprot	O60609
Product By Gene ID	2676
Alternate Names	GDNF family receptor alpha 3 GDNF family receptor alpha-3 GDNF R alpha-3 GDNF receptor alpha-3 GDNFR-alpha-3 GFR alpha3 GFR alpha-3 GFRA3 GFRa-3 GFR-alpha-3 glial cell line-derived neurotrophic factor receptor alpha-3 GPI-linked receptor

Research Areas for GFR alpha-3/GDNF R alpha-3

Find related products by research area and learn more about each of the different research areas below.

Cytokine Research
Immunology