GFR alpha-3/GDNF R alpha-3 Products

Description

Members of the glial cell line-derived neurotrophic factor (GDNF) family, including GDNF and neurturin (NTN), play key roles in the control of vertebrate neuronal survival and differentiation. A new member of the GDNF family was recently identified and designated persephin. Physiological responses to these neurotrophic factors require two receptor subunits, the novel glycosylphosphatidylinositol linked protein GFRalpha and Ret receptor tyrosine kinase GFRbeta. Following the identification of GFRalpha-1 and 2, another receptor in the GFR family was identified in human and mouse and designated GFRalpha-3. GFRalpha-3 binds persephin. Thus, persephin, GFRalpha-3, and Ret PTK form a complex to transmit the persephin signal and to mediate persephin function.

Bioinformatics

Entrez	14587 Mouse 2676 Human
Uniprot	AAC24355 Human AAH37951 Human NM_001496 Human O35118 Mouse O60609 Human
Product By Gene ID	2676
Alternate Names	GDNF family receptor alpha 3 GDNF family receptor alpha-3 GDNF receptor alpha-3 GDNFR-alpha-3 GFRa-3 GFR-alpha-3 glial cell line-derived neurotrophic factor receptor alpha-3 GPI-linked receptor

Research Areas for GFR alpha-3/GDNF R alpha-3

Find related products by research area and learn more about each of the different research areas below.

Cytokine Research
Immunology