Fas Ligand/TNFSF6 Products

Description

Fas / APO-1 (CD95) is an important member of the tumour necrosis factor (TNF) superfamily involved in membrane-mediated apoptosis. Ligation of Fas by Fas Ligand (Fas-L) or an anti-Fas cross-linking antibody, triggers activation of the caspase cascade. Functional impairment of the Fas / Fas-L system is associated with the development and progression of malignancies. Fas gene mutations have been suggested to have a role in testicular germ cell tumours. Tumour cells frequently exhibit de novo expression of Fas Ligand (Fas-L), which plays a significant role in local tissue destruction, metastatic spread, and immune escape of the tumor cells. The apoptosis of lymphocytes, which occurs in autoimmune diseases, is usually induced by the Fas/Fas-L system. Fas is believed to be involved in various autoimmune diseases including, ulcerative colitis, Graves disease, and rheumatoid arthritis. Fas expression on gastric epithelial cells in patients infected with H.Pylori is responsible for the accelerated apoptosis of the cells. Serum Fas-L concentration has also been shown to be associated with atherosclerosis and inflammatory disease, in patients with hypertension.

Bioinformatics

Entrez	14103 Mouse 25385 Rat 356 Human
Uniprot	AAH17502 Human AAH17502.1 Human NM_000639 Human NP_000630 Human P41047 Mouse P48023 Human Q544E9 Mouse
Product By Gene ID	356
Alternate Names	apoptosis (APO-1) antigen ligand 1 Apoptosis antigen ligand APT1LG1CD95L APTL CD178 antigen CD178 CD95-L Fas antigen ligand Fas ligand (TNF superfamily, member 6) Fas ligand FASLCD95 ligand TNFSF6FasL tumor necrosis factor (ligand) superfamily, member 6 tumor necrosis factor ligand superfamily member 6

Research Areas for Fas Ligand/TNFSF6

Find related products by research area and learn more about each of the different research areas below.

Adaptive Immunity
Apoptosis
Cancer
Diabetes Research
Immunology