EphA5 Products

Description

The EPHA5 gene encodes a member of a subfamily of the protein-tyrosine kinase family, an ephrin type-A receptor 5 receptor that exists in three isoforms: isoform 1: 1,037 amino acids long at 114 kDA; isoform 2: 1,015 amino acids long, 112 kDA; and isoform 3: 969 amino acids long at 107 kDA. Receptors of this family function in mediating developmental events especially in the nervous system. EPHA5 participates in the JNK pathway, P2Y receptor signaling, paxillin interactions, intracellular calcium signaling, and EphrinA-ephR signaling. It interacts with genes EFNA2, EFNA1, EFFNA3, EFNA5, and STAT3. EPHA4 is linked to pancreatitis, glioblastoma, cerebritis, ovarian cancer, adenocarcinoma, breast cancer and drug psychosis.

Bioinformatics

Entrez	13839 Mouse 2044 Human 79208 Rat
Uniprot	NP_004430 Human P54756 Human
Product By Gene ID	2044
Alternate Names	EC 2.7.10 EC 2.7.10.1 EHK-1 EHK1Hek7 EK7 EPH homology kinase 1 Eph homology kinase-1 EPH receptor A5 EphA5 EPH-like kinase 7 ephrin type-A receptor 5 hEK7 receptor protein-tyrosine kinase HEK7 TYRO4HEK7CEK7 tyrosine-protein kinase receptor EHK-1

Diseases related to EphA5

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Nervousness
Malignant Neoplasms
Neoplasms
Tissue Adhesions
Malignant Neoplasm Of Breast
Carcinoma
Glioblastoma
Glioma
Neoplasm Metastasis
Muscular Fasciculation
Tumor Angiogenesis
Liver Carcinoma
Optic Nerve Injuries
Malignant Paraganglionic Neoplasm
Epilepsy
Carcinogenesis
Osteosarcoma
Liposarcoma
Astrocytoma
Learning Disorders

Pathways for EphA5

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Axon Guidance
Regeneration
Cell Migration
Cell Adhesion
Brain Development
Segmentation
Dna Methylation
Localization
Methylation
Innervation
System Development
Demethylation
Angiogenesis
Cell Activation
Developmental Process
Protein Targeting
Axon Regeneration
Neurogenesis
Regulation Of Gene Expression
Myelination

Research Areas for EphA5

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Neuroscience
Protein Kinase

PTMs for EphA5

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Phosphorylation
Methylation
Demethylation
Reduction

Bioinformatics Tool for EphA5

Discover related pathways, diseases and genes to EphA5. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.