DFF40/CAD Products

Antibodies
Proteins
DFF40/CAD Recombinant Protein ...
DFF40/CAD Recombinant Protein
H00001677-P01
Species: Hu
Applications: WB, ELISA, PA
DFF40/CAD Partial Recombinant ...
DFF40/CAD Partial Recombinant Protein
H00001677-Q01
Species: Hu
Applications: WB, ELISA, PA
DFF40/CAD Peptide
DFF40/CAD Peptide
NBP1-76948PEP
Species: Mu
Applications: AC
RNAi
DFF40/CAD RNAi
DFF40/CAD RNAi
H00001677-R02
Species: Hu
Applications: RNAi, RNAi SP
DFF40/CAD RNAi
DFF40/CAD RNAi
H00001677-R03
Species: Hu
Applications: RNAi, RNAi SP
DFF40/CAD RNAi
DFF40/CAD RNAi
H00001677-R01
Species: Hu
Applications: RNAi, RNAi SP

Description

Apoptosis is related to many diseases and induced by a family of cell death receptors and their ligands. Cell death signals are transduced by death domain containing adapter molecules and members of the caspase family of proteases. These death signals finally cause the degradation of chromosomal DNA by activated DNase. A mouse DNase that causes DNA fragmentation was identified recently and designated CAD (for caspase activated deoxyribonuclease). The human homologue of mouse CAD was more recently identified by two groups independently and termed CPAN and DFF40. Human DFF45 and its mouse homologue ICAD are the inhibitors of CPAN/DFF40 and CAD, respectively (1, 2, 5). Upon cleavage of DFF45/ICAD by activated caspase, DFF40/CAD is released and activated and eventually causes the degradation of DNA in the nuclei. Activation of CAD/DFF40, which causes DNA degradation, is the hallmark of apoptotic cell death.

Bioinformatics

Entrez Human
Uniprot Human
Human
Human
Product By Gene ID 1677
Alternate Names
  • EC 3.-
  • Caspase-activated deoxyribonuclease
  • DFF-40DFF40DFF2DNA fragmentation factor subunit beta
  • CPANDNA fragmentation factor 40 kDa subunit
  • CADCaspase-activated nuclease
  • Caspase-activated DNase
  • DNA fragmentation factor, 40kDa, beta polypeptide (caspase-activated DNase)

Research Areas for DFF40/CAD

Find related products by research area and learn more about each of the different research areas below.

Apoptosis

PTMs for DFF40/CAD

Learn more about PTMs related to DFF40/CAD.

Cleavage
Phosphorylation
Deacetylation
Methylation
Oxidation
Dephosphorylation
Ubiquitination

Bioinformatics Tool for DFF40/CAD

Discover related pathways, diseases and genes to DFF40/CAD. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
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