Cyclin D1 Products

Antibodies
Cyclin D1 Antibody
Cyclin D1 Antibody
NBP2-24695
Species: Hu
Applications: WB, IHC-P
Host: Rabbit Polyclonal
Cyclin D1 Antibody (SP4)
Cyclin D1 Antibody (SP4)
Species: Hu, Mu, Rt, Bb
Applications: WB, ICC/IF, IHC, IHC-P
Host: Rabbit Monoclonal
Antibody Pairs
Cyclin D1 Antibody Pair
Cyclin D1 Antibody Pair
H00000595-PW2
Species: Hu
Applications: WB, IP
Lysates
Cyclin D1 Overexpression Lysa ...
Cyclin D1 Overexpression Lysate (D...
H00000595-T01
Species: Hu
Applications: WB
Cyclin D1 Overexpression Lysa ...
Cyclin D1 Overexpression Lysate (N...
NBL1-08871
Applications: WB
Proteins
Recombinant Human Cyclin D1 P ...
Recombinant Human Cyclin D1 Protein
H00000595-P01
Species: Hu
Applications: WB, ELISA, PA
Cyclin D1 Recombinant Protein ...
Cyclin D1 Recombinant Protein Antigen
NBP2-58667PEP
Species: Hu
Applications: B/N, Ctrl
RNAi
Cyclin D1 RNAi
Cyclin D1 RNAi
H00000595-R01
Species: Hu
Applications: RNAi, RNAi SP

Description

During the cell cycle of most somatic cells, DNA synthesis (S-phase) and mitosis (M-phase) are separated by two gap phases (G1 and G2) of varying duration. Thus, a typical eukaryotic cell sequentially passes through G1, S, G2, and M and back into G1 during a single cycle.12 Regulation of cell cycle progression in eukaryotic cells depends on the expression of cyclin proteins.13 These proteins are the regulatory subunits of the cyclin dependent kinases (CDKs), which are responsible for the phosphorylation of several cellular targets. Complexes of cyclins and CDKs play a key role in cell cycle control. Within the complexes, the cyclin subunit serves a regulatory role, whereas CDKs have a catalytic protein kinase activity.14 Members of the cyclin family of proteins combine with a CDK subunit to form the active kinase, which initiates G2 to M and G1 to S transition. The latter are controlled by cyclins termed G1 cyclins, which commit the cell to DNA replication. Therefore, the cell cycle can be considered as a cyclin cycle which is controlled by biochemical modifications and formation of complex(es) with CDKs.15 At least five candidate G1-phase cyclins, termed cyclins C, D1, D2, D3, and E have been identified in mammalian cells. Each of these cyclins can associate with one or more of the CDK family members. D-type cyclins are induced during the G1 phase of the mammalian cell cycle in response to a variety of mitogenic growth factors. The three distinct members of the D-type cyclin family are differentially and combinatorially xpressed in various cell lineages. Once induced, the D-type cyclins accumulate in complexes with CDKs, whose kinase activity is thought to be necessary for driving cells into S phase. The major catalytic partners of the D-type cyclins are CDK4 and CDK6, but at least some D-type cyclins also interat with other CDKs, including CDK2 and CDK5. Cyclin D1- and D2-associated CDK4 and/or CDK6 kinase activities have been detected in mid-G1, prior to the activation of any other known CDK, and they culminate in late G1 phase. The cyclin D3-associated CDK4 and/or CDK6 exhibit kinase activities at the G1/S transition. Cyclins D1, D2 and D3 can be distinguished by their slightly different mobilities on denaturing gels. Under these conditions, the apparent masses are 36, 33-35 and 31-34 kD for cyclins D1, D2 and D3, respectively. Because D-type cyclins probably serve as integrators of growth factor-induced signals with the cell cycle clock, aberrant expression of these proteins might play a role in disrupting the normal timing of events governing G1 progression and, in so doing, contribute to oncogenesis. Indeed, a link between tumor formation and inappropriate expression of cyclins has been established.16,17 Overexpression of this protein as a result of chromosomal rearrangement, occurs in parathyroid tumors and centrocytic lymphomas, and amplification of the cyclin D1 gene has been observed in a significant percentage of other cancers, including breast, squamous, and esophageal arcinomas. Immunochemical techniques provide a convenient and sensitive method for detection of these cyclins in human tumor tissues. Such assays facilitate studies directed toward correlating the phenotypic subtypes and aggressiveness of particular human tumors known to exhibit cyclin D1 overexpression and enable studies with other types in which cyclins D2 and D3 are similarly implicated in pathogenesis. The availability of monoclonal antibody reacting specifically with cyclin D1 enables the subcellular detection and localization of cyclin D1 and the measurement of relative differences in cyclin D1 levels as a function of cell cycle phase.

Bioinformatics

Entrez Human
Mouse
Rat
Uniprot Human
Human
Human
Human
Human
Human
Human
Human
Product By Gene ID 595
Alternate Names
  • PRAD1 oncogene
  • BCL-1
  • BCL-1 oncogene
  • G1/S-specific cyclin-D1
  • B-cell lymphoma 1 protein
  • G1/S-specific cyclin D1
  • U21B31
  • PRAD1B-cell CLL/lymphoma 1
  • BCL1D11S287E
  • cyclin D1 (PRAD1: parathyroid adenomatosis 1)
  • cyclin D1

Research Areas for Cyclin D1

Find related products by research area and learn more about each of the different research areas below.

Cancer
Cell Cycle and Replication
Core ESC-Like Genes
mTOR Pathway
Stem Cell Markers
Wnt Signaling Pathway

Bioinformatics Tool for Cyclin D1

Discover related pathways, diseases and genes to Cyclin D1. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
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Related Cyclin D1 Blog Posts

Check out the latest blog posts on Cyclin D1.
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The dynamic use of a PCNA antibody in fish, porcine and primate species
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Transportin 1 and heterogeneous nuclear ribonucleoprotein D (hnRNPD)
Transportin 1, also known as Karyopherin- beta 2 or Importin- beta 2, is part of the beta -karyopherins family, which consists of importins and exportins responsible for the active transport of proteins between the nucleus and cytoplasm.  Transportin 1 is co...    Read more.
Beta-catenin - I am versatile!
Beta-catenin is a cytosolic, 88 kDa intracellular protein associated with cell surface cadherin glycoproteins. It is a member of the larger calcium-dependent catenin family that includes alpha-catenin, beta-catenin, and gamma-catenin (also known as pl...    Read more.
IKK alpha says "no" to NFk beta
The nuclear factor kappa B (NFkB) is a ubiquitous transcription factor essential for the activation of immune and inflammatory responses. NFkB activity is inhibited when it is associated with IkB proteins in the cell cytoplasm. IkB proteins are phosph...    Read more.
Beta Catenin Implications for Signaling
The Wnt/beta Catenin signaling pathway plays a critical role in embryonic development, stem cell self-renewal and regeneration. Alterations in this signaling cascade have been implicated in the pathogenesis of cancer. Notably, chronic activation of Wn...    Read more.
Role of RASSF1A in Death Receptor-Dependent Apoptosis
Death-receptor apoptosis, or cell death, is essential for cellular growth regulation; its disruption is expressed in a variety of cancers. We at Novus Biologicals are one of the leading antibody suppliersfor apoptosis and cancer research groups, and t...    Read more.
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