CXCR4 Products

Antibodies
Lysates
CXCR4 Overexpression Lysate ( ...
CXCR4 Overexpression Lysate (Denat...
H00007852-T02
Species: Hu
Applications: WB
CXCR4 Overexpression Lysate ( ...
CXCR4 Overexpression Lysate (Native)
NBL1-09633
Applications: WB
Proteins
CXCR4 Recombinant Protein
CXCR4 Recombinant Protein
H00007852-G01
Species: Hu
CXCR4 Recombinant Protein
CXCR4 Recombinant Protein
H00007852-P01
Species: Hu
Applications: WB, ELISA, PA
CXCR4 Partial Recombinant Pro ...
CXCR4 Partial Recombinant Protein
H00007852-Q01
Species: Hu
Applications: WB, ELISA, PA
RNAi
CXCR4 RNAi
CXCR4 RNAi
H00007852-R04
Species: Hu
Applications: RNAi, RNAi SP
CXCR4 RNAi
CXCR4 RNAi
H00007852-R03
Species: Hu
Applications: RNAi, RNAi SP

Description

CD184, also known as fusin or CXCR4, is a 45 kD seven transmembrane G-protein-linked CXC chemokine receptor. CD184 is widely expressed on blood and tissue cells, including B and T cells, monocytes, macrophages, dendritic cells, granulocytes, megakaryocytes/platelets, lymphoid, myeloid precursor cells, endothelial cells, epithelial cells, astrocytes, and neurons, among other tissue cells. CD184 is the receptor for CXC chemokine SDF-1, mediates blood cell migration, and is involved in B lympho- and myelopoiesis, cardiogenesis, blood vessel formation and cerebellar development. CXCR4 is also a coreceptor of X4 HIV-1 and an alternative receptor for some isolates of HIV-2. The 12G5 antibody has been reported to block CD4-independent infection by HIV-2 and CD4-dependent infection by some T cell-tropic isolates of HIV-1.

Bioinformatics

Entrez Human
Mouse
Rat
Uniprot Human
Human
Human
Human
Human
Mouse
Product By Gene ID 7852
Alternate Names
  • FB22
  • Fusin
  • CXCR-4
  • seven-transmembrane-segment receptor, spleen
  • CXC-R4
  • seven transmembrane helix receptor
  • Stromal cell-derived factor 1 receptor
  • neuropeptide Y receptor Y3
  • Leukocyte-derived seven transmembrane domain receptor
  • lipopolysaccharide-associated protein 3
  • fusin
  • leukocyte-derived seven-transmembrane-domain receptor
  • NPYY3R
  • C-X-C chemokine receptor type 4
  • NPYR
  • LAP3
  • HSY3RR
  • chemokine (C-X-C motif), receptor 4 (fusin)
  • CD184
  • NPY3RWHIM
  • D2S201ESDF-1 receptor
  • LESTRCD184 antigen
  • HM89NPYRL
  • LCR1
  • chemokine (C-X-C motif) receptor 4

Research Areas for CXCR4

Find related products by research area and learn more about each of the different research areas below.

Adaptive Immunity
Cancer
Cytokine Research
GPCR
Growth and Development
Immunology
Innate Immunity
Neuronal Cell Markers
Signal Transduction

Bioinformatics Tool for CXCR4

Discover related pathways, diseases and genes to CXCR4. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
Vizit™, under license from BioVista Inc.

Related CXCR4 Blog Posts

Check out the latest blog posts on CXCR4.
LAMP2: Protector of the lysosome
LAMP2 belongs to the family of membrane glycoproteins who confer selectins with carbohydrate ligands. LAMP2 has been implicated in tumor cell metastasis, as well as overall protection, maintenance, and adhesion of the lysosome. It appears that LAMP2 m...    Read more.
CXCR4 Studies on Neural and Stem Cells
The CXCR4 (C-X-C chemokine receptor type 4) protein is one member of the G-protein coupled receptor (GPCR1) family. As a multipass membrane protein that is found in several tissues, it is the receptor for the C-X-C chemokine CXCL12/SDF-1. The CXCR4 li...    Read more.
Understanding CXCR4 and SDF1
CXCR4 (C-X-C chemokine receptor type 4) is a member of the G-protein coupled receptor (GPCR1) family. It is expressed as a multipass membrane protein in several tissues where it acts as the receptor for the C-X-C chemokine CXCL12/SDF-1. This ligand in...    Read more.
Read more CXCR4 related blogs.