CXCR4 Products

Description

CD184, also known as fusin or CXCR4, is a 45 kD seven transmembrane G-protein-linked CXC chemokine receptor. CD184 is widely expressed on blood and tissue cells, including B and T cells, monocytes, macrophages, dendritic cells, granulocytes, megakaryocytes/platelets, lymphoid, myeloid precursor cells, endothelial cells, epithelial cells, astrocytes, and neurons, among other tissue cells. CD184 is the receptor for CXC chemokine SDF-1, mediates blood cell migration, and is involved in B lympho- and myelopoiesis, cardiogenesis, blood vessel formation and cerebellar development. CXCR4 is also a coreceptor of X4 HIV-1 and an alternative receptor for some isolates of HIV-2. The 12G5 antibody has been reported to block CD4-independent infection by HIV-2 and CD4-dependent infection by some T cell-tropic isolates of HIV-1.

Bioinformatics

Entrez	12767 Mouse 60628 Rat 7852 Human
Uniprot	AAH20968 Human AAH20968.1 Human NP_001008540 Human NP_003458 Human P61073 Human P70658 Mouse
Product By Gene ID	7852
Alternate Names	CD184 chemokine (C-X-C motif) receptor 4 chemokine (C-X-C motif), receptor 4 (fusin) C-X-C chemokine receptor type 4 CXC-R4 CXCR-4 D2S201ESDF-1 receptor FB22 Fusin fusin HM89NPYRL HSY3RR LAP3 LCR1 LESTRCD184 antigen Leukocyte-derived seven transmembrane domain receptor leukocyte-derived seven-transmembrane-domain receptor lipopolysaccharide-associated protein 3 neuropeptide Y receptor Y3 NPY3RWHIM NPYR NPYY3R pCXCR4 seven transmembrane helix receptor seven-transmembrane-segment receptor, spleen Stromal cell-derived factor 1 receptor

Research Areas for CXCR4

Find related products by research area and learn more about each of the different research areas below.

Adaptive Immunity
Cancer
Cytokine Research
GPCR
Growth and Development
Immunology
Innate Immunity
Neuronal Cell Markers
Signal Transduction

Related CXCR4 Blog Posts

Check out the latest blog posts on CXCR4.

Understanding CXCR4 and SDF1 CXCR4 (C-X-C chemokine receptor type 4) is a member of the G-protein coupled receptor (GPCR1) family. It is expressed as a multipass membrane protein in several tissues where it acts as the receptor for the C-X-C chemokine CXCL12/SDF-1. This ligand in...    Read more.

CXCR4 Studies on Neural and Stem Cells The CXCR4 (C-X-C chemokine receptor type 4) protein is one member of the G-protein coupled receptor (GPCR1) family. As a multipass membrane protein that is found in several tissues, it is the receptor for the C-X-C chemokine CXCL12/SDF-1. The CXCR4 li...    Read more.

LAMP2: Protector of the lysosome LAMP2 belongs to the family of membrane glycoproteins who confer selectins with carbohydrate ligands. LAMP2 has been implicated in tumor cell metastasis, as well as overall protection, maintenance, and adhesion of the lysosome. It appears that LAMP2 m...    Read more.

Stemness is responsible for onset and metastasis of colorectal cancer By Jamshed Arslan, Pharm. D., PhD. Colorectal cancer stem cells are a rare subpopulation of colorectal cancer cells that can self-renew and initiate and sustain tumor growth when transplanted into an animal host.1,2 C...    Read more.

Read more CXCR4 related blogs.