CIP2A Products

CIP2A Antibody
CIP2A Antibody
Species: Hu, Mu, Rt, Bovine, Primate, Bat, Rhesus Macaque
Applications: WB, ICC/IF, IHC, IHC-P, IP
Host: Rabbit Polyclonal
CIP2A Antibody
CIP2A Antibody
Species: Hu, Mu
Applications: WB, Flow, ICC/IF, IHC, IHC-P
Host: Rabbit Polyclonal
CIP2A Overexpression Lysate ( ...
CIP2A Overexpression Lysate (Native)
Applications: WB


Inhibition of protein phosphatase 2A (PP2A) activity has been identified as a prerequisite for the transformation of human cells. The protein, designated Cancerous Inhibitor of PP2A (CIP2A), interacts directly with the oncogenic transcription factor c-Myc, inhibits PP2A activity toward c-Myc serine 62 (S62), and thereby prevents c-Myc proteolytic degradation. In addition to its function in c-Myc stabilization, CIP2A promotes anchorage-independent cell growth and in vivo tumor formation. The oncogenic activity of CIP2A is demonstrated by transformation of human cells by overexpression of CIP2A. Importantly, CIP2A is overexpressed in two common human malignancies, head and neck squamous cell carcinoma (HNSCC) and colon cancer.


Entrez Human
Uniprot Human
Product By Gene ID 57650
Alternate Names
  • p90
  • protein CIP2A
  • p90 autoantigen
  • CIP2A
  • MGC163436
  • Cancerous inhibitor of PP2A
  • FLJ12850
  • KIAA1524

Research Areas for CIP2A

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Tumor Suppressors

PTMs for CIP2A

Learn more about PTMs related to CIP2A.


Bioinformatics Tool for CIP2A

Discover related pathways, diseases and genes to CIP2A. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
Vizit™, under license from BioVista Inc.

Related CIP2A Blog Posts

Check out the latest blog posts on CIP2A.
CIP2A - A lean, mean, oncoprotein machine
The CIP2A protein was originally identified as p90, a cytoplasmic auto-antigen from the serum of a cancer patient. It was later found to inhibit protein phosphatase 2A (PP2A) activity as well as interact with c-myc. CIP2A's inhibitory activity blocks...    Read more.
CIP2A: The Cancerous Inhibitor of Protein Phosphatase 2A
The autoantigen p90 is a recently discovered protein that binds to and inhibits Protein Phosphatase 2A (PP2A) activity, thereby playing a critical role in cancer progression. Thus, p90 was renamed the "cancerous inhibitory protein of PP2A" or CIP2A....    Read more.
Read more CIP2A related blogs.