WB, Flow, ICC/IF, IPHost:
Species: Hu, Mk, Pm
Applications: ICC/IF, IHC, IHC-P
Host: Rabbit Polyclonal
Applications: WB, ELISA, PA
CENPF (Centromere protein F) is required for proper chromosome segregation in mitosis, and has a cell-cycle distribution that is both temporally regulated and diverse in terms of the structural component localization. Specifically, CENPF is a component of the nuclear matrix during the G2 phase of interphase. In late G2, it associates with the kinetochore and maintains this association through early anaphase. Here, CENPF is required for kinetochore function and appears to be the earliest member to interact with the centromere-kinetochore complex. It then localizes to the spindle midzone in late anaphase and to the intracellular bridge in telophase, where the protein is subsequently degraded. Given this diversity of function, CENPF is expected to play an important role in several mitotic events.
|Product By Gene ID
- centromere protein F (350/400kD, mitosin)
- centromere protein F, 350/400ka (mitosin)
- AH antigen
- centromere protein F
- Kinetochore protein CENPF
- CENP-F kinetochore protein
- cell-cycle-dependent 350K nuclear protein
- centromere protein F, 350/400kDa (mitosin)
Bioinformatics Tool for CENPF
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Related CENPF Blog Posts
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|CENPF: At the Center-o'-mere Mitotic Division (Infographic)
Centromere protein F (CENPF) also known as Mitosin, AH antigen, and kinetochore protein CENPF, is a protein that associates with the centromere-kinetochore complex. CENPF forms both a homodimer and a heterodimer. CENPF can be found in different cellul... Read more.
|CENPF Antibodies as Potential Cancer Markers
Centromere protein F (CENPF), also named mitosin, is a large human protein of 3113 amino acid residues. Its expression and localization are cell cycle-dependent. The protein levels are low in G1 phase but elevated from S to early M phase. CENPF is a n... Read more.