BORIS Products

Description

BORIS (Brother of the Regulator of Imprinted Sites) also known as CCTC-binding factor-like protein, is normally only expressed in the testis and expressed in a mutually exclusive manner with CTCF during male germ cell development. However, previous studies have shown that BORIS is abnormally activated in a wide range of human cancers. Expression of BORIS in normally BORIS-negative cells promotes cell growth that may lead to transformation. BORIS maps to the cancer-associated amplification region thought to contain an oncogene or dominant-immortalizing gene. BORIS is a candidate protein for the epigenetic reprogramming factor acting in the male germ line. BORIS is found in both the nucleus and cytoplasm.

Bioinformatics

Entrez	140690 Human
Uniprot	NM_080618 Human NP_542185 Human Q8NI51 Human
Product By Gene ID	140690
Alternate Names	BORISHMGB1L1 BORIS-like protein Brother of the regulator of imprinted sites Cancer/testis antigen 27 CCCTC-binding factor (zinc finger protein)-like CCCTC-binding factor CT27MGC163358 CTCF paralog CTCF-like protein CTCF-T dJ579F20.2 HMG-1L1 MGC169105 MGC169106 putative high mobility group protein 1-like 1 putative high mobility group protein B1-like 1 transcriptional repressor CTCFL Zinc finger protein CTCF-T