B7-1/CD80 Products

Antibodies
Antibody Pairs
B7-1/CD80 Antibody Pair
B7-1/CD80 Antibody Pair
H00000941-PW2
Species: Hu
Applications: WB, IP
B7-1/CD80 Antibody Pair
B7-1/CD80 Antibody Pair
H00000941-PW4
Species: Hu
Applications: WB, IP
B7-1/CD80 Antibody Pair
B7-1/CD80 Antibody Pair
H00000941-PW3
Species: Hu
Applications: WB, IP
ELISA Kits
B7-1/CD80 ELISA Kit [Biotin]
B7-1/CD80 ELISA Kit [Biotin]
KA0991
Species: Mu
Lysates
B7-1/CD80 Overexpression Lysa ...
B7-1/CD80 Overexpression Lysate (N...
NBP2-07780
Applications: WB
B7-1/CD80 Overexpression Lysa ...
B7-1/CD80 Overexpression Lysate (D...
H00000941-T01
Species: Hu
Applications: WB
Proteins
B7-1/CD80 Recombinant Protein ...
B7-1/CD80 Recombinant Protein
NBP2-26578
B7-1/CD80 Recombinant Protein ...
B7-1/CD80 Recombinant Protein Antigen
NBP2-48954PEP
Species: Hu
Applications: AC
B7-1/CD80 Recombinant Protein ...
B7-1/CD80 Recombinant Protein
NBP2-50554
Species: Mu
Applications: PAGE
RNAi
B7-1/CD80 RNAi
B7-1/CD80 RNAi
H00000941-R01
Species: Hu
Applications: RNAi, RNAi SP

Description

The B-lymphocyte activation antigen B7-1 (CD80) provides regulatory signals for T lymphocytes as a consequence of binding to the CD28 and CTLA4 ligands of T cells. After engagement of T-cell receptor with antigen in association with major histocompatibility complex class II, a second signal mediated through the binding of B7 to CD28 greatly upregulates the production of multiple lymphokines (1). The relatively small CTLA-4/B7-1 binding interface exhibits an unusually high degree of shape complementarity. CTLA-4 forms homodimers through a newly defined interface of highly conserved residues. This zipper-like oligomerization provides the structural basis for forming unusually stable signalling complexes at the T-cell surface, underscoring the importance of potent inhibitory signalling in human immune responses (2).

Bioinformatics

Entrez Human
Mouse
Rat
Uniprot Human
Human
Human
Human
Mouse
Rat
Product By Gene ID 941
Alternate Names
  • CD28LG1
  • CD80 antigen
  • BB1
  • T-lymphocyte activation antigen CD80
  • B7
  • costimulatory molecule variant IgV-CD80
  • Activation B7-1 antigen
  • costimulatory factor CD80
  • CD28LGB7-1 antigen)
  • CTLA-4 counter-receptor B7.1
  • CD80 molecule

Research Areas for B7-1/CD80

Find related products by research area and learn more about each of the different research areas below.

Adaptive Immunity
Cytokine Research
Immunology
Signal Transduction

Bioinformatics Tool for B7-1/CD80

Discover related pathways, diseases and genes to B7-1/CD80. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
Vizit™, under license from BioVista Inc.

Related B7-1/CD80 Blog Posts

Check out the latest blog posts on B7-1/CD80.
CD80: A co-stimulator of T cell activation
CD80 is a 60kD single chain type I transmembrane glycoprotein that is a member of the immunoglobulin family. CD80 is expressed on activated B- and T-lymphocytes, as well as a subpopulation of previously activated B-cells, but not on the majority of re...    Read more.
Read more B7-1/CD80 related blogs.