B7-1/CD80 Products

Description

The B-lymphocyte activation antigen B7-1 (CD80) provides regulatory signals for T lymphocytes as a consequence of binding to the CD28 and CTLA4 ligands of T cells. After engagement of T-cell receptor with antigen in association with major histocompatibility complex class II, a second signal mediated through the binding of B7 to CD28 greatly upregulates the production of multiple lymphokines (1). The relatively small CTLA-4/B7-1 binding interface exhibits an unusually high degree of shape complementarity. CTLA-4 forms homodimers through a newly defined interface of highly conserved residues. This zipper-like oligomerization provides the structural basis for forming unusually stable signalling complexes at the T-cell surface, underscoring the importance of potent inhibitory signalling in human immune responses (2).

Bioinformatics

Entrez	12519 Mouse 25408 Rat 941 Human
Uniprot	AAH42665 Human NP_005182 Human NP_005182.1 Human O55202 Rat P33681 Human Q00609 Mouse
Product By Gene ID	941
Alternate Names	Activation B7-1 antigen B7 BB1 CD28LG1 CD28LGB7-1 antigen) CD80 antigen CD80 molecule costimulatory factor CD80 costimulatory molecule variant IgV-CD80 CTLA-4 counter-receptor B7.1 T-lymphocyte activation antigen CD80

Research Areas for B7-1/CD80

Find related products by research area and learn more about each of the different research areas below.

Adaptive Immunity
Cytokine Research
Immunology
Signal Transduction

Related B7-1/CD80 Blog Posts

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CD80: A co-stimulator of T cell activation CD80 is a 60kD single chain type I transmembrane glycoprotein that is a member of the immunoglobulin family. CD80 is expressed on activated B- and T-lymphocytes, as well as a subpopulation of previously activated B-cells, but not on the majority of re...    Read more.

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