Hu, Mu, Rt, PmApplications:
WB, Simple Western, ChIP, GS, ICC/IF, IHC, IHC-Fr, IHC-P, IPHost:
Hu, Mu, Rt, Pm, RbApplications:
WB, Simple Western, B/N, ChIP, ICC/IF, IHC, IHC-Fr, IHC-P, IPHost:
Species: Hu, Mu, Rt
Applications: WB, Simple Western
Host: Goat Polyclonal
Hu, Mu, RtApplications:
WB, ICC/IF, IHC, IP
DNA-(apurinic or apyrimidinic site) lyase, also known as APE1 or APEX1, is a multifunctional mammalian proteins responsible for the cellular response to oxidative stress. Specifically, APE-1 both functions in the DNA base excision repair pathway and regulates the redox of transcriptional factors.
For DNA repair, APE1 functions as a mammalian apurinic/apyrimidinic (AP) endodeoxyribonuclease responsible for the repair of AP sites in DNA lesions induced by oxidative and alkylating agents.
APEX1 also exerts a reversible nuclear redox activity to regulate the DNA binding affinity and the activity of transcriptional factors by regulating the redox status of their DNA-binding domains.
APE1 antibodies are useful for studies on both DNA repair and transcriptional regulation.
Bioinformatics Tool for APE
Discover related pathways, diseases and genes to APE. Need help? Read the Bioinformatics Tool Guide
for instructions on using this tool.