APE Products

Antibodies
APE Antibody (13B8E5C2)
APE Antibody (13B8E5C2)
NB100-116
Species: Hu, Mu, Rt, Pm
Applications: WB, Simple Western, ChIP, GS, ICC/IF, IHC, IHC-Fr, IHC-P, IP
Host: Mouse Monoclonal
APE Antibody
APE Antibody
Species: Hu, Mu, Rt, Pm, Rb
Applications: WB, Simple Western, B/N, ChIP, ICC/IF, IHC, IHC-Fr, IHC-P, IP
Host: Rabbit Polyclonal
APE Antibody (200913)
APE Antibody (200913)
MAB1044
Species: Hu, Mu, Rt
Applications: WB
Host: Mouse Monoclonal
Antibody Packs
APE Antibody Pack
APE Antibody Pack
NB100-909
Species: Hu, Mu, Rt
Applications: WB, ICC/IF, IHC, IP
Lysates
APE Overexpression Lysate (De ...
APE Overexpression Lysate (Denatured)
H00000328-T01
Species: Hu
Applications: WB
APE Overexpression Lysate (Na ...
APE Overexpression Lysate (Native)
NBP2-05771
Applications: WB
APE Overexpression Lysate (Na ...
APE Overexpression Lysate (Native)
NBL1-07598
Applications: WB
Proteins
APE Full Length Recombinant P ...
APE Full Length Recombinant Protein
NB100-101PEP
Species: Hu
APE Recombinant Protein
APE Recombinant Protein
NBP1-72280
Species: Hu
Applications: PAGE
RNAi
APE RNAi
APE RNAi
H00000328-R01
Species: Hu
APE RNAi
APE RNAi
H00000328-R02
Species: Hu
APE RNAi
APE RNAi
H00000328-R03
Species: Hu

Description

DNA-(apurinic or apyrimidinic site) lyase, also known as APE1 or APEX1, is a multifunctional mammalian proteins responsible for the cellular response to oxidative stress. Specifically, APE-1 both functions in the DNA base excision repair pathway and regulates the redox of transcriptional factors.

For DNA repair, APE1 functions as a mammalian apurinic/apyrimidinic (AP) endodeoxyribonuclease responsible for the repair of AP sites in DNA lesions induced by oxidative and alkylating agents.

APEX1 also exerts a reversible nuclear redox activity to regulate the DNA binding affinity and the activity of transcriptional factors by regulating the redox status of their DNA-binding domains.

APE1 antibodies are useful for studies on both DNA repair and transcriptional regulation.

Bioinformatics

Entrez Human
Mouse
Rat
Uniprot Human
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Human
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Human
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Product By Gene ID 328
Alternate Names
  • APE
  • APEX nuclease
  • AP endonuclease 1
  • EC 3.1
  • APE1
  • redox factor 1
  • Redox factor-1
  • protein REF-1
  • Apurinic-apyrimidinic endonuclease 1
  • multifunctional DNA repair enzyme
  • REF-1
  • DNA-(apurinic or apyrimidinic site) lyase
  • APE-1
  • APEX deoxyribonuclease (apurinic or apyrimidinic)
  • REF1 apurinic/apyrimidinic exonuclease
  • HAP1apurinic/apyrimidinic (abasic) endonuclease
  • APXAP lyase
  • APENAP endonuclease class I
  • APEAPEX nuclease (multifunctional DNA repair enzyme)
  • EC 4.2.99.18
  • APEX nuclease (multifunctional DNA repair enzyme) 1

Research Areas for APE

Find related products by research area and learn more about each of the different research areas below.

Autophagy
Base Excision Repair
Cancer
Core ESC-Like Genes
DNA Repair
Stem Cell Markers

Bioinformatics Tool for APE

Discover related pathways, diseases and genes to APE. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
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