Species: Hu, Mu, Rt, Pm
Applications: WB, Simple Western, ELISA, Func, GS, ICC/IF, IHC, IP, ChIP, Mycoplasma
Host: Mouse Monoclonal
Species: Hu, Mu, Rt, Pm, Rb
Applications: WB, Simple Western, Flow, ICC/IF, IHC, IP, B/N, ChIP, IHC
Host: Rabbit Polyclonal
Species: Hu, Mu, Rt
Applications: WB, ICC/IF, IHC
Host: Rabbit Polyclonal
Species: Hu
Applications: PAGE
Species: Hu
Applications: AC
Description
DNA-(apurinic or apyrimidinic site) lyase, also known as APE1 or APEX1, is a multifunctional mammalian proteins responsible for the cellular response to oxidative stress. Specifically, APE-1 both functions in the DNA base excision repair pathway and regulates the redox of transcriptional factors.
For DNA repair, APE1 functions as a mammalian apurinic/apyrimidinic (AP) endodeoxyribonuclease responsible for the repair of AP sites in DNA lesions induced by oxidative and alkylating agents.
APEX1 also exerts a reversible nuclear redox activity to regulate the DNA binding affinity and the activity of transcriptional factors by regulating the redox status of their DNA-binding domains.
APE1 antibodies are useful for studies on both DNA repair and transcriptional regulation.
Bioinformatics
| Product By Gene ID |
328 |
| Alternate Names |
- AP endonuclease 1
- APE
- APE1
- APE-1
- APEAPEX nuclease (multifunctional DNA repair enzyme)
- APENAP endonuclease class I
- APEX deoxyribonuclease (apurinic or apyrimidinic)
- APEX nuclease (multifunctional DNA repair enzyme) 1
- APEX nuclease
- APEX1
- Apurinic-apyrimidinic endonuclease 1
- APXAP lyase
- DNA-(apurinic or apyrimidinic site) lyase
- EC 3.1
- EC 4.2.99.18
- HAP1apurinic/apyrimidinic (abasic) endonuclease
- multifunctional DNA repair enzyme
- protein REF-1
- redox factor 1
- Redox factor-1
- REF1 apurinic/apyrimidinic exonuclease
- REF-1
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