IRE1 alpha and ER Stress: Keys to Disease Progression Pathways

Fri, 09/21/2012 - 08:00

Inositol Requiring Enzyme 1 alpha (IRE1 alpha) is a transmembrane-RNase with an endoplasmic reticulum (ER) luminal sensor domain and cytosolic kinase and ribonuclease domains. IRE1 also plays a central role in the ER stress response (1). In a recent study the function of nitric oxide (NO) in endoplasmic reticulum (ER)-related cell death in human glioma cells was investigated by treating these cells with a NO donor S-nitroso-N-acetyl-d,l-penicillamine and thapsigargin, an ER stress inducer, resulting in cell death. Expression of the ER-associated molecules IRE1 alpha was elevated as detected by Western blotting (2) suggesting IRE1 alpha may play a role in the ER related cell death. Activated IRE1 and ER stress in various cells plays an important role in the pathogenesis of several diseases, including obesity, type 2 diabetes, cancer, and intestinal bowel and airway diseases suggesting that ER stress-induced inflammation contributes substantially to disease progression (3). Targeting IRE1 may contribute towards a better therapeutic regimen for these diseases.

- Detection of phosphorylated Ire1 alpha in Min6 cells, treated with glucose for 3 hours, using NB 100-2323."]Westerm Blot: IRE-1 alpha antibody [NB100-2323 Westerm Blot: IRE-1 alpha antibody [NB100-2323
  1. PMID: 15952902
  2. PMID: 20447464
  3. PMID: 22883813


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