Adropin – A Cure For Greed?

Wed, 03/17/2010 - 13:46

We at Novus Biologicals have a large number of products in our antibody database which are used for metabolic research. A new Adropin antibody is a recent addition, and is used in obesity research. Although not life-threatening in its own right, obesity – as we all know - can lead to a host of more serious illnesses including heart disease, stroke and diabetes.

The role of adropin is to regulate lipid metabolism and control glucose homeostasis. It is encoded by the ENHO (Energy Homeostasis Associated) gene, and is found in the liver and brain. Studies have shown the protein levels rise in response to the intake of fatty foods, and fall during fasting. This makes adropin one of the first proteins proven to react directly to dietary fat intake.

Western Blot: Adropin Antibody Western Blot: Adropin Antibody

Now, it has been suggested adropin could hold the key to preventing onset of diabetes. Obese mice are normally unable to metabolize adropin. However, genetically obese animals that were given it in dosage form responded better to insulin and had less fatty livers than the controls. The benefits were seen long before they began losing weight. A synthetic version of the peptide gave similar results to that derived from in vivo sources.

These results suggest that adropin could be a useful therapeutic tool, but there is still a lot to learn. For example, since it is produced in both the liver and the brain, it would be interesting to see if there is a connection. Recently, we at Novus Biologicals, antibodies suppliers tested a new batch of rabbit polyclonal anti-adropin antibody in our lab, using human brain lystate as the substrate. It will be interesting to see if obesity really is "all in the mind."

Novus Biologicals offers many Adropin reagents for your research needs including:


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