Blogs for June 2021

Pyroptosis: Mechanisms mediating cell death and pro-inflammatory cytokine release

Friday, June 18, 2021 - 15:49
Immunohistochemical staining of formalin-fixed tissue of adenocarcinoma of the rectum using Caspase-1 antibody, peroxidase conjugate, and DAB chromogen.

By Victoria Osinski

Pyroptosis is an inflammatory form of programmed cell death characterized by the release of pro-inflammatory cytokines IL-1β and IL-18.1,10 It is a process distinct from apoptosis and necrosis (Table 1) and has been observed in the setting of multiple diseases including, but...

COVID-19 and metabolic dysregulation: SARS-CoV-2 injures human exocrine and endocrine pancreas

Thursday, June 3, 2021 - 17:55
Immunohistochemical staining of paraffin-embedded rat pancreas tissue with insulin antibody (red) and NKX6.1 antibody (green).

Jamshed Arslan, Pharm D, PhD

Humans rely on the pancreas for digesting food and generating energy from it. SARS-CoV-2-mediated damage to the exocrine pancreas is evident from the pancreatitis, pancreatic enlargement, and abnormal levels of digestive enzymes in severe COVID-19. Likewise, increased propensity for hyperglycemia,...


Blog Topics


Archives