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Pyroptosis Pathway Bioinformatics

Disease and disorder research has been conducted in relation to the Pyroptosis Pathway and Inflammation, Infective Disorder, Salmonella Infections, Bacterial Infections, Legionnaires' Disease. The study of the Pyroptosis Pathway has been mentioned in research publications which can be found using our bioinformatics tool below. The Pyroptosis Pathway has been researched in relation to Cell Death, Secretion, Virulence, Programmed Cell Death, Autophagy. The Pyroptosis Pathway complements our catalog of research reagents including antibodies and ELISA kits against CASPASE 1, IL-1BETA, NLR, CASPASE 3, PARP1.

Pyroptosis Bioinformatics Tool

Laverne is a handy bioinformatics tool to help facilitate scientific exploration of related genes, diseases and pathways based on co-citations. Explore more on Pyroptosis below! For more information on how to use Laverne, please read the How to Guide.
Vizit™, under license from BioVista Inc.

Top Research Reagents

We have 1308 products for the study of the Pyroptosis Pathway that can be applied to Western Blot, Chromatin Immunoprecipitation, Immunocytochemistry/Immunofluorescence, Flow Cytometry, Immunohistochemistry from our catalog of antibodies and ELISA kits.

NB100-56565
Western Blot: Caspase-1 Antibody (14F468) [NB100-56565] - Analysis of Caspase-1 using a Caspase-1 monoclonal antibody. Human HeLa (A) and mouse NIH3T3 lysate probed with Caspase-1 antibody at 0.5 ug/ml and 2 ug/ml, respectively.Immunohistochemistry-Paraffin: Caspase-1 Antibody (14F468) [NB100-56565] - IHC analysis of a formalin fixed paraffin embedded (FFPE) tissue section of human intestine using Caspase-1 antibody (clone 14F468) at 5ug/ml concentration (1:200 dilution). The primary antibody binding to Caspase 1 in cells was detected using HRP conjugated anti-Mouse secondary antibody with DAB reagent, and the sections were further counterstained with hematoxylin for labeling cellular nuclei. This Caspase 1 antibody generated a diffused but specific cytoplasmic staining in columnar epithelia cells of villi, and a few cells depicted nuclear staining also. Only a subset of connective tissue cells in lamina propria depicted positivity (cytoplasmic) for this protein.

Mouse Monoclonal
Species Human, Mouse, Rat
Applications WB, Simple Western, IHC

25 Publications
NB100-56142

Rabbit Polyclonal
Species Human, Mouse
Applications WB, IHC, IHC-Fr

1 Publication
NBP2-12446
Western Blot: NLRP3/NALP3 Antibody [NBP2-12446] -  Analysis of NALP3 using NALP3 antibody. Lane A) human NALP3 transfected cell lysate this antibody, B) mouse NALP3 transfected cell lysate this antibody, and C) HEK293 control lysate probed with NALP3 antibody at 3 ug/ml.Immunohistochemistry-Paraffin: NLRP3/NALP3 Antibody [NBP2-12446] - Analysis of formalin fixed paraffin-embedded (FFPE) human esophagus using NLRP3/NALP3 antibody at 1:50 on a Bond Rx autostainer (Leica Biosystems). The assay involved 20 minutes of heat induced antigen retrieval (HIER) using 10mM sodium citrate buffer (pH 6.0) and endogenous peroxidase quenching with peroxide block. The sections were incubated with primary antibody for 30 minutes and Bond Polymer Refine Detection (Leica Biosystems) with DAB was used for signal development followed by counterstaining with hematoxylin. Whole slide scanning and capturing of representative images was performed using Aperio AT2 (Leica Biosystems). Cytoplasmic staining in the squamous epithelium was observed. Staining was performed by Histowiz.

Rabbit Polyclonal
Species Human, Mouse, Rat
Applications WB, ICC/IF, IHC

     3 Reviews

36 Publications
NBP1-78977
Western Blot: ASC/TMS1 Antibody [NBP1-78977] - Western Blot Image of anti-ACS/TMS1. Whole cell protein from THP1 (lane 1) and HL60 (lane 2) was separated on a 4-15% gel by SDS-PAGE, transferred to 0.2 um PVDF membrane and blocked in 5% non-fat milk in TBST. The membrane was probed with 4.0 ug/ml anti-ACS/TMS1 in 1% milk, and detected with an anti-rabbit HRP secondary antibody using chemiluminescence.Immunocytochemistry/Immunofluorescence: ASC/TMS1 Antibody [NBP1-78977] - ASC/TMS1 antibody was tested in MCF-7 cells with FITC (green). Nuclei and alpha-tubulin were counterstained with DAPI (blue) and Dylight 550 (red).

Rabbit Polyclonal
Species Human, Mouse, Rat
Applications WB, Simple Western, ICC/IF

     2 Reviews

5 Publications
NBP1-90095
Immunohistochemistry-Paraffin: Steroid sulfatase Antibody [NBP1-90095] - Staining of human placenta shows high expression.Immunohistochemistry: Steroid sulfatase Antibody [NBP1-90095] - Staining of human cerebellum shows strong cytoplasmic positivity in purkinje cells.

Rabbit Polyclonal
Species Human
Applications IHC, IHC-P

3 Publications
H00009447-B01P
Western Blot: AIM2 Antibody [H00009447-B01P] - Analysis of AIM2 expression in transfected 293T cell line by AIM2 polyclonal antibody.  Lane 1: AIM2 transfected lysate(37.73 KDa). Lane 2: Non-transfected lysate.Immunocytochemistry/Immunofluorescence: AIM2 Antibody [H00009447-B01P] - Analysis of purified antibody to AIM2 on HeLa cell. (antibody concentration 10 ug/ml)

Mouse Polyclonal
Species Human
Applications WB, ELISA, ICC/IF

4 Publications
NBP1-54899
Western Blot: NLRP1/NALP1 Antibody [NBP1-54899] - Human Fetal Brain, Antibody Dilution: 1.0 ug/ml.Western Blot: NLRP1/NALP1 Antibody [NBP1-54899] - NCI-H226 cell lysate, concentration 0.2-1 ug/ml.

Rabbit Polyclonal
Species Human, Mouse
Applications WB, ICC/IF, IHC

5 Publications
NB100-56708
Western Blot: Caspase-3 Antibody (31A1067) - (Pro and Active) [NB100-56708] - Analysis using the Azide Free version of NB100-56708. Detection of Caspase-3 activation in HeLa cells. Cells were treated with 2mM staurosporine for different time periods. Caspase-3 activation is determined by cleavage of procaspase-3.Western Blot: Caspase-3 Antibody (31A1067) - (Pro and Active) [NB100-56708] - Western Blot Image of anti-Caspase 3 (31A1067).  Whole cell protein from Jurkat cells treated with and without 2 uM staurosporine as indicated was separated on a 4-15% gel by SDS-PAGE, transferred to 0.2 um PVDF membrane and blocked in 5% non-fat milk in TBST.  The membrane was probed with 5 ug/ml anti-Caspase 3 in 1% milk, and detected with an anti-mouse HRP secondary antibody using a Femto sensitivity chemiluminescence reagent.  Note the detection of both pro-caspase 3 at 35 kDa and the cleaved active caspase 3 at 15-17 kDa.

Mouse Monoclonal
Species Human, Mouse, Rat
Applications WB, Simple Western, EM

     1 Review

113 Publications
NBP2-13732
Western Blot: PARP Antibody [NBP2-13732] - Analysis in RT-4 cells transfected with control siRNA, target specific siRNA probe #1 and #2. Remaining relative intensity is presented. Loading control: Anti-GAPDH.Immunocytochemistry/Immunofluorescence: PARP Antibody [NBP2-13732] - Immunofluorescent staining of human cell line HEK 293 shows localization to nucleus. Antibody staining is shown in green.

Rabbit Polyclonal
Species Human
Applications WB, ICC/IF, IHC

     1 Review

1 Publication
NBP1-90044
Immunocytochemistry/Immunofluorescence: ATN1 Antibody [NBP1-90044] - Staining of human cell line U-251 MG shows localization to nucleoplasm.Immunohistochemistry-Paraffin: ATN1 Antibody [NBP1-90044] - Staining in human cerebral cortex and liver tissues using anti-ATN1 antibody. Corresponding ATN1 RNA-seq data are presented for the same tissues.

Rabbit Polyclonal
Species Human
Applications ICC/IF, IHC, IHC-P

1 Publication
210-TA
Recombinant Human TNF-alpha  (Catalog # 210‑TA) induces cytotoxicity in the L-929 mouse fibroblast cell line in the presence of the metabolic inhibitor actinomycin D. The ED<sub>50</sub> for this effect is 25‑100 pg/mL.1 µg/lane of Recombinant Human TNF-alpha  was resolved by SDS-PAGE with silver staining, under reducing (R) conditions, showing a band at 17 kDa.


Species Human

     19 Reviews

506 Publications
201-LB
1 μg/lane of Recombinant Human IL-1 beta /IL-1F2 was resolved with SDS-PAGE under reducing (R) conditions and visualized by silver staining, showing a single band at 17 kDa.Recombinant Human IL-1 beta /IL-1F2 (Catalog # 201-LB) stimulates cell proliferation of the D10.G4.1 mouse helper T cell line. The ED<SUB>50</SUB> for this effect is <12 pg/mL.


Species Human

     6 Reviews

325 Publications
8884-LY


Species Human

3 Publications