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By Jamshed Arslan, Pharm. D., PhD.
It was 1988 when, after decades of research, Dr. GM Reaven of the Stanford University, CA, explained the relationship between four diseases: insulin resistance, hypertension, diabetes and obesity....
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By Michalina Hanzel, PhD
Fused in sarcoma (FUS) is a ribonucleoprotein that continuously shuttles between the nucleus and the cytoplasm to regulate pre-mRNA splicing, mRNA stability and mRNA transport. Mutations in FUS are found in 4% familial and 1% sporadic cases of amyotrophic lateral...
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By Rosa Moreno, PhD.
Physiological low levels of oxygen induce normal hypoxic events across biological systems. This hypoxic state activates hypoxia inducible factors (HIFs) to regulate transcription by binding to the hypoxia response element (HRE) region of...
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By Jamshed Arslan, Pharm. D., PhD.
Stroke is a leading cause of mortality and morbidity worldwide. Cellular players – neurons, astrocytes, endothelial and stromal cells – involved in post-stroke repair through angiogenesis...
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By Jamshed Arslan, Pharm. D., PhD.
Gastroesophageal adenocarcinoma originates from the glandular epithelium of the esophagus, gastroesophageal junction and stomach. The incidence of gastroesophageal adenocarcinoma is declining, but it is still one of the deadliest cancers worldwide. A key reason behind high mortality is that by the time gastroesophageal adenocarcinoma is diagnosed, the cancer has often already metastasized. The search for novel biomarkers underlying gastroesophageal...
