SOCS-3 Products

Description

The SOCS3 (suppressor of cytokine signaling-3) protein is a 25 kD cytoplasmic protein that contains a SOCS box and an SH2 domain. SOCS3 has been shown to be involved the negative regulation of cytokine signaling via JAK/STAT pathway. SOCS3 has been shown to inhibit IL-2, IL-3, IL-4, IL-6, erythropoietin, prolactin, and growth hormone. SOCS3 has also been shown to regulate erythropoiesis in the fetal liver. SOCS3 is induced induced by inflammation, erythropoietin, GM-CSF, IL-10, and IFN- gamma. SOCS3 can be modified by JAK phophorylation which destabilizes the protein and ubiquitination which targets for destruction by the proteosome. SOCS3 has been shown to interact with the IGF-1 receptor, insulin receptor, gp130 receptor, erythropoietin receptor, leptin receptor, LIF receptor, JAK2, and elongin C. The SOC-25 monoclonal antibody recognizes human and mouse SOCS3 and has been shown to be useful for Western blotting.

Bioinformatics

Entrez	12702 Mouse
Uniprot	O35718 Mouse
Product By Gene ID	9021
Alternate Names	ATOD4 CIS3 CIS3CIS-3 Cish3 cytokine-induced SH2 protein 3 Cytokine-inducible SH2 protein 3 SOCS3 SOCS-3 SOCS-3STAT-induced STAT inhibitor 3 SSI-3 SSI-3ATOD4 SSI3MGC71791 suppressor of cytokine signaling 3

Research Areas for SOCS-3

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Signal Transduction