Species: Hu, Mu, Rt
Applications: WB, Flow, ICC/IF, IHC
Host: Mouse Monoclonal
Species: Hu
Applications: WB, ELISA, ICC/IF
Host: Mouse Monoclonal
Species: Hu
Applications: ICC/IF, IHC
Host: Rabbit Polyclonal
Species: Hu
Applications: WB
Species: Hu
Applications: PAGE
Description
This gene encodes a protein similar to the RAS effector proteins. Loss or altered expression of this gene has been associated with the pathogenesis of a variety of cancers, which suggests the tumor suppressor function of this gene. The inactivation of this gene was found to be correlated with the hypermethylation of its CpG-island promoter region. The encoded protein was found to interact with DNA repair protein XPA. The protein was also shown to inhibit the accumulation of cyclin D1, and thus induce cell cycle arrest. Seven alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq]. Transcript Variant: This variant (A) lacks an in-frame coding segment compared to variant D, resulting an isoform (A) that lacks an internal region, as compared to isoform D. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Bioinformatics
| Product By Gene ID |
11186 |
| Alternate Names |
- 123F2
- NORE2A
- pancreas-specific ras association domain family 1 protein
- Ras association (RalGDS/AF-6) domain family member 1
- ras association domain-containing protein 1
- RASSF1A
- RDA32cardiac-specific ras association domain family 1 protein
- REH3P21
- tumor suppressor protein RDA32
- WUGSC:H_LUCA12.5
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