RANK/TNFRSF11A Products

Description

Apoptosis, or programmed cell death, occurs during normal cellular differentiation and development of multicellular organisms. Apoptosis is induced by certain cytokines including TNF and Fas ligand of the TNF family through their death domain containing receptors, TNFR1 and Fas. Receptor activator of NF-kB (RANK) is a recently cloned member of the TNFR superfamily with no significant homology to other members of this family (1). RANK ligand (RANKL/TRANCE/ OPGL) (mAbs to RANKL is also available from Imgenex, Cat # IMG-133) binds to RANK on dendritic cells, upregulates the expression of anti-apoptotic protein BcL-XL suggesting a role in dendritic cell survival (2). The cytoplasmic domain of RANK interacts with TRAF2, TRAF5 and TRAF6 (3,4). Overexpression of RANK activates NF-kB and c-Jun-terminal kinase (JNK) pathways (3). Recent studies have shown that RANK interaction with TRAF6 activates NF-kB, whereas JNK activation is mediated through binding of RANK to TRAF2 (4).

Bioinformatics

Entrez	21934 Mouse 8792 Human
Uniprot	NM_003839 Human NP_003830 Human O35305 Mouse Q9Y6Q6 Human Q9Y6Q6.1 Human
Product By Gene ID	8792
Alternate Names	CD265 antigen CD265 FEO loss of heterozygosity, 18, chromosomal region 1 ODFROSTS OFE OPTB7 Osteoclast differentiation factor receptor PDB2 RANKLOH18CR1 Receptor activator of NF-KB receptor activator of nuclear factor-kappa B TRANCER tumor necrosis factor receptor superfamily member 11A tumor necrosis factor receptor superfamily, member 11a, activator of NFKB tumor necrosis factor receptor superfamily, member 11a, NFKB activator

Research Areas for RANK/TNFRSF11A

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Cell Cycle and Replication