TMEM59 Antibody (816004) [Alexa Fluor™ Plus 680]

• Reactivity: Hu
• Clone: 816004
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Alexa Fluor Plus 680

TMEM59 Antibody (816004) [Alexa Fluor™ Plus 680] Summary

• Specificity: Detects human TMEM59 in direct ELISAs.
• Isotype: IgG1
• Clonality: Monoclonal
• Host: Mouse

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied
• Buffer: Supplied 0.2 mg/mL in a saline solution containing BSA and Sodium Azide.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for TMEM59 Antibody (816004) [Alexa Fluor™ Plus 680]

• C1orf8
• chromosome 1 open reading frame 8
• DCF1
• FLJ42977
• HSPC001
• Liver membrane-bound protein
• PRO195
• TMEM59
• transmembrane protein 59
• UNQ169

Background

TMEM59 is a 324 aa protein with a 21 amino acid transmembrane domain which localizes to the Golgi compartment where it modulates the O-glycosylation and complex N-glycosylation maturation steps of several proteins including APP, BACE1, SEAP and PRNP. It may retain APP in the Golgi and inhibits amyloid beta generation as well APP cleavage by alpha and beta secretases. TMEM59 also contains a 19 aa peptide that acts as a regulator of autophagy in response to bacterial infection by promoting LC3 activation through interaction with ATG16L1, targeting its own endosomal compartment to lysosomes in response to aggregation during S.areus infection.

1. Ullrich S, et al, J Biol Chem. 2010 Jul 2;285(27):20664
2. Boada-Romero E, et al, EMBO J. 2013 Feb 20;32(4):566

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.