SRPK3/STK23 Antibody (722516) [Alexa Fluor® 750]

• Reactivity: Hu
• Applications: WB, IHC
• Clone: 722516
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Alexa Fluor 750

SRPK3/STK23 Antibody (722516) [Alexa Fluor® 750] Summary

• Immunogen: E. coli-derived recombinant human SRPK3
  Arg247-Ser316
  Accession # Q9UPE1
• Specificity: Detects human SRPK3 in direct ELISAs and Western blots.
• Isotype: IgG1
• Clonality: Monoclonal
• Host: Mouse
• Purity Statement: Protein A or G purified

Applications/Dilutions

• Dilutions:
  • Immunohistochemistry
  • Western Blot

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied
• Buffer: Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for SRPK3/STK23 Antibody (722516) [Alexa Fluor® 750]

• MGC102944
• MSSK1
• MSSK-1
• MSSK1EC 2.7.11.1
• Muscle-specific serine kinase 1
• serine arginine rich protein-specific kinase 3
• Serine/arginine-rich protein-specific kinase 3
• serine/threonine kinase 23
• Serine/threonine-protein kinase 23
• serine/threonine-protein kinase SRPK3
• SFRS protein kinase 3
• SRPK3
• SR-protein-specific kinase 3
• SRSF protein kinase 3
• STK23

Background

SRPK3 (Ser/Arg-rich protein specific kinase 3), also called MSSK-1 (muscle-specific serine kinase 1) or STK23 (Ser/Thr kinase 23) is a 59 kDa (predicted) cytoplasmic member of the CMGC Ser/Thr protein kinase family. SRPK3 is principally expressed in heart and skeletal muscle. SRPKs selectively phosphorylate Ser on RS domain-containing proteins, initiating mRNA splicing and maturation.  The 533 amino acid (aa) human SRPK3 contains a split kinase domain (aa 79‑292 and 347‑531) separated by a hinge region. A 491 aa isoform shows an alternate translation start site at aa 43. Within the region used as an immunogen, human SRPK3 shares 87% and 86% aa identity with mouse and rat SRPK3, respectively.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.