Recombinant Human PRMT1 Protein

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Product Details

Summary
Reactivity HuSpecies Glossary
Applications PAGE, Bioactivity

Order Details

Recombinant Human PRMT1 Protein Summary

Description
Recombinant protein for Human PRMT1

Source:E. coli
Amino Acid Sequence:(Q99873)

Source
E. coli
Protein/Peptide Type
Recombinant Protein
Gene
PRMT1
Purity
>90%, by SDS-PAGE

Applications/Dilutions

Application Notes
Specific activity: 10,000 units/ml. Unit definition: One unit will transfer 1 pmol of methyl group to synthetic peptide of histone H4 in 10 minutes at 37 degrees C.
Theoretical MW
84 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Packaging, Storage & Formulations

Storage
Store at -20 to -80C. Avoid freeze-thaw cycles.
Buffer
40 mM Tris-HCl (pH 8.0), 100 mM NaCl, 4 mM MgCl2, 2 mM DTT, 40% glycerol
Purity
>90%, by SDS-PAGE

Alternate Names for Recombinant Human PRMT1 Protein

  • ANM1
  • EC 2.1.1
  • EC 2.1.1.-
  • EC 2.1.1.125
  • EC 2.1.1.77
  • HCP1
  • Histone-arginine N-methyltransferase PRMT1
  • HMT1 (hnRNP methyltransferase, S. cerevisiae)-like 2
  • HMT1 hnRNP methyltransferase-like 2 (S. cerevisiae)
  • HMT1
  • HMT2
  • HRMT1L2
  • HRMT1L2HMT1 hnRNP methyltransferase-like 2
  • Interferon receptor 1-bound protein 4
  • IR1B4
  • IR1B4protein arginine N-methyltransferase 1
  • PRMT1
  • protein arginine methyltransferase 1

Background

PRMT1 methylate's (mono & asymmetric dimethylation) the guanidino nitrogens of arginyl residues present in a glycine and arginine-rich domain (may methylate HNRNPA1 and histones) methylate's SUPT5H. The PRMT1 protein functions as a histone methyltransferase specific for H4. PRMT1 is an essential factor in oncogenesis and is a potential novel therapeutic target in cancer. PRMT1-mediated methylation serves as a positive modulator of IR/IRS-1/PI3K pathway and glucose uptake in skeletal muscle cells. CAF1 is a new regulator of PRMT1-dependent arginine methylation. PRMT1 arginine-methylate's MRE11 therefore it regulates the activity of MRE11-RAD50-NBS1 complex during the intra-S-phase DNA damage checkpoint response. PRMT1 plays a post-translationally part in regulating the transcriptional activity. PRMT1 is found predominantly in the cytoplasm, though a fraction of PRMT1 is located in the nucleus.PRMT1 Human Recombinant (a.a. 1-353) fused with His-MBP tag at N-terminus produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 750 amino acids and having a molecular mass of 84 kDa. The PRMT1 is purified by proprietary chromatographic techniques.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Peptides and proteins are guaranteed for 3 months from date of receipt.

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Blogs on PRMT1.

PRMT6: One Function, Many Roles
Protein arginine methylation is a prevalent posttranslational modification in eukaryotic cells. It regulates RNA processing, trafficking and nascent pre-RNA metabolism, receptor-mediated signal transduction, and transcriptional activation processes. P...  Read full blog post.

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Bioinformatics

Gene Symbol PRMT1
Entrez