Histone H2AE [p Ser1] Antibody (RM216) [Alexa Fluor™ Plus 680]

• Reactivity: Hu, Vb
• Applications: WB, ELISA, ICC/IF
• Clone: RM216
• Clonality: Monoclonal
• Host: Rabbit
• Conjugate: Alexa Fluor Plus 680

Histone H2AE [p Ser1] Antibody (RM216) [Alexa Fluor™ Plus 680] Summary

• Additional Information: Recombinant Monoclonal Antibody
• Immunogen: An unmodified peptide corresponding to the N-terminus of Histone H2AE
• Modification: p Ser1
• Specificity: This antibody reacts to Histone H4 or Histone H2AE phosphorylated at Serine 1. No cross reactivity with other phosphorylated Histones.
• Isotype: IgG
• Clonality: Monoclonal
• Host: Rabbit
• Gene: H2AC8
• Purity: Protein A purified

Applications/Dilutions

• Dilutions:
  • ELISA
  • Immunocytochemistry/ Immunofluorescence
  • Western Blot
• Application Notes: Optimal dilution of this antibody should be experimentally determined.

Packaging, Storage & Formulations

• Storage: Store at 4C in the dark.
• Buffer: 50mM Sodium Borate
• Preservative: 0.05% Sodium Azide
• Purity: Protein A purified

Notes

This product is provided under an intellectual property license from Life Technologies Corporation. The transfer of this product is conditioned on the buyer using the purchased product solely in research conducted by the buyer, excluding contract research or any fee for service research, and the buyer must not (1) use this product or its components for (a) diagnostic, therapeutic or prophylactic purposes; (b) testing, analysis or screening services, or information in return for compensation on a per-test basis; or (c) manufacturing or quality assurance or quality control, and/or (2) sell or transfer this product or its components for resale, whether or not resold for use in research. For information on purchasing a license to this product for purposes other than as described above, contact Life Technologies Corporation, 5781 Van Allen Way, Carlsbad, CA 92008 USA or outlicensing@thermofisher.com. This conjugate is made on demand. Actual recovery may vary from the stated volume of this product. The volume will be greater than or equal to the unit size stated on the datasheet.

Alternate Names for Histone H2AE [p Ser1] Antibody (RM216) [Alexa Fluor™ Plus 680]

• H2A histone family, member M
• H2A/m
• H2AFA
• H2AFMHistone H2A/m
• HIST1H2AE
• histone 1, H2ab
• histone cluster 1, H2ab
• histone H2A type 1-B/E
• Histone H2A.2
• Histone H2A/a

Background

Histone H2AE is 124 amino acids long, weighing approximately 13 kDa, and is part of a group of basic nuclear proteins called histones, which are responsible for nucleosome structure of the chromosomal fiber in eukaryotes and is a core component of the nucleosome. Current studies are being done on several diseases and disorders including riddle syndrome, systemic lupus erythematosus, lupus srythematosus, and immunodeficiency. This protein has also been shown to have interactions with HIST1H4A, HIST1H4B, HIST1H4C, HIST1H4D, and HIST1H4E in pathways such as the proteasome degradation, nucleosome assembly, cell cycle, and systemic lupus erythematosus pathways.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: H2AC8