Coronin-2B Antibody

Product Discontinued

Coronin-2B Antibody Summary

• Immunogen: Peptide with sequence C-QLQLELKNLRNSPK corresponding to C-Terminus according to NP_006082.3.
• Specificity: This epitope was chosen to prevent cross-reactivity with hypothetical protein XP_121721.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Goat
• Gene: CORO2B
• Purity: Immunogen affinity purified

Applications/Dilutions

• Dilutions:
  • Peptide ELISA Detection limit 1:16000
• Application Notes: WB: Preliminary experiments gave no signal but low background in human brain and testis lysates at up to 1 ug/ml.
• Control:

  Coronin-2B Overexpression Lysate

Packaging, Storage & Formulations

• Storage: Store at -20C. Avoid freeze-thaw cycles.
• Buffer: Tris saline (20 mM Tris pH 7.3, 150 mM NaCl), 0.5% BSA
• Preservative: 0.02% Sodium Azide
• Concentration: 0.5 mg/ml
• Purity: Immunogen affinity purified

Notes

Please note, this antibody is considered Innovators Grade. Innovators Grade antibodies are generally unvalidated and require additional characterization for most new species/applications. Novus has made these antibodies available through our Innovators Reward program. Complete an online review with image, detailing your positive or negative results. In return, you receive a discount voucher for 100% of the purchase price of the reviewed product. Please contact us at innovators@novusbio.com for more details.

Alternate Names for Coronin-2B Antibody

• clipin C
• ClipinC
• Clipin-C
• coronin, actin binding protein, 2B
• coronin, actin-binding protein, 2B
• coronin, actin-binding, 2B
• coronin-2B
• Coronin-like protein C
• KIAA0925clipin-C
• Protein FC96

Background

Research results indicate that ClipinC is a component part of the cross bridge between the actin cytoskeleton and the plasma membrane. These findings and the previously reported function of coronin suggest that ClipinC may play specific roles in the reorganization of neuronal actin structure, a change that has been implicated in both cell motility and growth cone advance.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for Coronin-2B Antibody (NB100-1430)(1)

Publication using NB100-1430

• Nakamura T, Takeuchi K, Muraoka S et al. A neurally enriched coronin-like protein, ClipinC, is a novel candidate for an actin cytoskeleton-cortical membrane-linking protein. J Biol Chem 1999-05-07 [PMID: 10224093]

Bioinformatics

• Gene Symbol: CORO2B
• Entrez:
  • 10391(Human)
  • 235431(Mouse)
• Uniprot:
  • NP_006082.(Human)