Aflatoxin B1 Antibody (6A10) [FITC]

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Product Details

Summary
Reactivity AllSpecies Glossary
Applications ELISA, ICC/IF, IHC-Fr, IHC-P
Clone
6A10
Clonality
Monoclonal
Host
Mouse
Conjugate
FITC

Aflatoxin B1 Antibody (6A10) [FITC] Summary

Immunogen
Aflatoxin B1 DNA (against the midazole ring-opened persistent form of the major N-7 guanine adduct of AFB1).
Localization
Nuclear
Isotype
IgG1 Kappa
Clonality
Monoclonal
Host
Mouse
Purity
Protein G purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • ELISA
  • Immunocytochemistry/Immunofluorescence
  • Immunohistochemistry-Frozen
  • Immunohistochemistry-Paraffin
Application Notes
This Aflatoxin B1 antibody is useful for ELISA, Immunohistochemistry, Immunocytochemistry/Immunofluorescence and Western blot. Immunohistochemistry-Frozen, Dot Blot and Immunohistochemistry-Paraffin were reported in scientific literature.

Reactivity Notes

All species. There is no cross-reactivity with other carcinogen-DNA adducts.

Packaging, Storage & Formulations

Storage
Store at 4C in the dark.
Buffer
PBS
Preservative
0.05% Sodium Azide
Purity
Protein G purified

Notes

This conjugate is made on demand. Actual recovery may vary from the stated volume of this product. The volume will be greater than or equal to the unit size stated on the datasheet.

Alternate Names for Aflatoxin B1 Antibody (6A10) [FITC]

  • AFB1
  • AFB1-AR1
  • Aldoketoreductase 7

Background

Aflatoxins (AF) are a group of harmful fungal toxins commonly found as grains/groundnuts contaminants and the most abundant congeners of AF, aflatoxin B1 (AFB1) is the most toxic among AFs which is produced by Aspergillus flavus, A. parasiticus etc. Humans and domestic animals can be exposed to aflatoxins by foods and approximately 25% of the world's food supply is annually contaminated with mycotoxins indicating the widespread prevalence of this public health problem. AFB1, a potent hepatotoxin/hepatocarcinogen, undergoes metabolism catalyzed by mixed function oxygenases of hepatic cytochrome P-450 enzyme system to produce a highly reactive intermediate, aflatoxin B1-8,9 epoxide that binds to necleophilic sites in hepatocyte DNA to form a number of adducts. The reactive aflatoxin B1-8,9 epoxide attracts guanine residues in double stranded DNA and the adducts formation leads to initiation of hepatocarcinogenesis. ROS generated during aflatoxins metablosm are considered to be main culprit for hepatotoxicity. The AFB1-8,9-epoxide can further be converted to AFB1-8,9-diol that specifically binds to lysine in albumin and forms AFB1-lysine adducts (AFB-Lys), which has been validated as a biomarker of human aflatoxins exposure.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Product General Protocols

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Video Protocols

ICC/IF Video Protocol

FAQs for Aflatoxin B1 Antibody (NB600-443F) (0)

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Secondary Antibodies

 

Isotype Controls

Other Available Formats

Biotin Labeled NB600-443B
DyLight 350 Labeled NB600-443UV
DyLight 405 Labeled NB600-443V
DyLight 488 Labeled NB600-443G
DyLight 550 Labeled NB600-443R
DyLight 650 Labeled NB600-443C
DyLight 680 Labeled NB600-443FR
DyLight 755 Labeled NB600-443IR
HRP Labeled NB600-443H

Additional Aflatoxin B1 Products

Research Areas for Aflatoxin B1 Antibody (NB600-443F)

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Blogs on Aflatoxin B1.

Using Aflatoxin B1 Antibody for Hepatocellular Carcinoma Studies
We at Novus Biologicals are constantly updating our antibody catalog in order to provide as comprehensive a database as possible for molecular biology researchers. Not all our antibodies are derived from proteins found in mammalian or human tissue. So...  Read full blog post.

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