3-OHKYN Antibody (P3UI) [DyLight 405]


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Product Details

Reactivity Hu, AllSpecies Glossary
Applications WB, ICC/IF
Please see the vial label for concentration. If unlisted please contact technical services.

3-OHKYN Antibody (P3UI) [DyLight 405] Summary

3-OHKYN modified KLH
This is specific for 3-hydroxykynureinine (3OH-Kyn) modifications on proteins. It is likely to react with 3OH-Kyn modification on lysine, histidine and cysteine residues on proteins. It does not react with enzymes involved in the degradation of tryptopha
IgG1 Kappa
Protein G purified
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Packaging, Storage & Formulations

Store at 4C in the dark.
DyLight 405
DyLight 405 (A=400, E=420)
50mM Sodium Borate
0.05% Sodium Azide
Please see the vial label for concentration. If unlisted please contact technical services.
Protein G purified


Application Notes
This 3-OHKYN antibody is useful for Immunocytochemistry/Immunofluorescence and Western blot, where a band is seen at ~66 kDa. Immunohistochemistry-Paraffin, and ELISA were reported in scientific literature.

The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
Theoretical MW
66 kDa

Reactivity Notes

Human, although there should be no species limitation to this antibody's reactivity.


Dylight (R) is a trademark of Thermo Fisher Scientific Inc. and its subsidiaries.

Alternate Names for 3-OHKYN Antibody (P3UI) [DyLight 405]

  • 3039Hydroxykynurenine
  • 3-hydroxykynuenine modification


3-OHKYN (3-Hydroxykynurenine) is tryptophan's toxic metabolite which is capable of inducing oxidative damage as well as cell death consequently contributing to different neurological and psychiatric disorders. Tryptophan is either transaminated to kynurenate (an endogenous glutamate receptor antagonist), or hydroxylated to 3-OHKYN which is degraded to excitotoxic N-methyl-D-aspartate (NMDA) agonist, quinolinate. Under physiological conditions, kynurenine pathway is activated to form metabolic precursor NAD+; however, under inflammatory, oxidative or neurotoxic attack, there is an increased activation of indoleamine dioxygenase (IDO), kynurenine monooxygenase (KMO) and tryptophan dioxygenase (TDO), yielding the formation of toxic metabolites such as 3-OHKYN and quinolinic acid. Once 3-OHKYN crosses neuronal cell membranes through neutral amino acid transporter (NAT), it can follow two routes: (i) may act as ROS scavenger/antioxidant via direct scavenging or by triggering integral antioxidant responses evoked by transcription signaling pathways, such as the Nrf2/Keap1/ARE axis (ii) 3-OHKYN may undergoes autooxidation yielding highly reactive molecules, such as o-aminoquinone, which in turn causes exacerbated oxidative damage, activation of deadly cascades, and massive cell death.


This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Product General Protocols

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Video Protocols

WB Video Protocol
ICC/IF Video Protocol

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Secondary Antibodies


Isotype Controls

Other Available Formats

Allophycocyanin Labeled NB100-597APC
Biotin Labeled NB100-597B
DyLight 350 Labeled NB100-597UV
DyLight 405LS Labeled NB100-597V3
DyLight 488 Labeled NB100-597G
DyLight 550 Labeled NB100-597R
DyLight 650 Labeled NB100-597C
DyLight 680 Labeled NB100-597FR
DyLight 755 Labeled NB100-597IR
FITC Labeled NB100-597F
HRP Labeled NB100-597H
PE Labeled NB100-597PE
PerCP Labeled NB100-597PCP

Additional 3-OHKYN Antibody (P3UI) [DyLight 405] Products

3-OHKYN NB100-597V

Research Areas for 3-OHKYN Antibody (NB100-597V)

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