p63/TP73L Products

Description

This gene encodes a member of the p53 family of transcription factors. An animal model, p63 -/- mice, has been useful in defining the role this protein plays in the development and maintenance of stratified epithelial tissues. p63 -/- mice have several developmental defects which include the lack of limbs and other tissues, such as teeth and mammary glands, which develop as a result of interactions between mesenchyme and epithelium. Mutations in this gene are associated with ectodermal dysplasia, and cleft lip/palate syndrome 3 (EEC3); split-hand/foot malformation 4 (SHFM4); ankyloblepharon-ectodermal defects-cleft lip/palate; ADULT syndrome (acro-dermato-ungual-lacrimal-tooth); limb-mammary syndrome; Rap-Hodgkin syndrome (RHS); and orofacial cleft 8. Both alternative splicing and the use of alternative promoters results in multiple transcript variants encoding different proteins. Many transcripts encoding different proteins have been reported but the biological validity and the full-length nature of these variants have not been determined

Bioinformatics

Entrez	8626 Human 22061 Mouse 246334 Rat
Uniprot	Q9H3D4
Product By Gene ID	8626
Alternate Names	amplified in squamous cell carcinoma Chronic ulcerative stomatitis protein CUSP EEC3 EEC3B(p51B) Keratinocyte transcription factor KET KET KETRHS LMS OFC8 OFC8SHFM4TP73LNBP p40 p51 p51tumor protein p53-like p53CP p63 p63AIS P73H p73L p73LB(p51A) SHFM4 TP53CP TP53L TP63 TP73L Transformation-related protein 63 tumor protein 63 tumor protein p53-competing protein tumor protein p63 deltaN isoform delta tumor protein p63 Tumor protein p73-like

Research Areas for p63/TP73L

Find related products by research area and learn more about each of the different research areas below.

Apoptosis
Cancer
Cellular Markers
Hypoxia
Stem Cell Markers
Tumor Suppressors

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