TBK1 Products

Description

NFkappaB-activating kinase (NAK) also known as TANK binding kinase-1 (TBK1) or tumor necrosis factor receptor associated factor 2-associated kinase (T2K) is a serine/threonine protein that belongs to the IkB kinase (IKK) family (1). Similar to IKK alpha and beta (2), NAK induces IkB degradation and NF-kB activity. NAK is activated by phorbol ester tumour promoters and growth factors, whereas catalytically inactive NAK specifically inhibits activation of NF-kB by protein kinase C-epsilon (PKCepsilon). NAK specifically phosphorylates IkB alpha on Serine 36 and NFkB subunit RelA (p65) on Serine 536 (3). NAK is also known to interact with TANK, TRAF-2 and TRIF (4).

Bioinformatics

Product By Gene ID	29110
Alternate Names	EC 2.7.11 EC 2.7.11.1 FLJ11330 FTDALS4 NAK serine/threonine-protein kinase TBK 1 NAK NAKserine/threonine-protein kinase TBK1 NF-kappa-B-activating kinase NFKB-Activating Kinase T2K TANK-binding kinase 1NF-kB-activating kinase TBK 1 TBK1

Research Areas for TBK1

Find related products by research area and learn more about each of the different research areas below.

Protein Kinase
Signal Transduction

Related TBK1 Blog Posts

Check out the latest blog posts on TBK1.

Autophagy Research Update: What a difference a year makes! By Christina Towers, PhD Over the last two decades the field of autophagy has exploded! Innovative techniques, comprehensive analysis and disease-relevant models have yielded basic and clinical discoveries of conseque...    Read more.

STING in Innate Immunity and Cancer: What’s the Buzz About? STING (STimulator of INterferon Genes protein) acts as a sensor of cytosolic DNA. Bacteria/Virus or self-derived DNA in the cytosol activates the STING pathway and promotes the production of type I interferons (IFN-alpha and IFN-beta). STING also ...    Read more.

Read more TBK1 related blogs.