IKK gamma Products

Description

NF-kB (nuclear factor kB) is sequestered in the cytoplasm by IkB family of inhibitory proteins that mask the nuclear localization signal of NF-kB thereby preventing translocation of NF-kB to the nucleus. External stimuli such as tumor necrosis factor or other cytokines results in phosphorylation and degradation of IkB releasing NF-kB dimers. NF-kB dimer subsequently translocates to the nucleus and activates target genes. Synthesis of IkBa is autoregulated. IkB proteins are phosphorylated by IkB kinase complex consisting of at least three proteins, IKK1/a, IKK2/b, and IKK3/g. IKK3/g preferentially interacts with IKK2/b and is required for activation of IKK complex. IKK3/g is also known as NEMO (NF-kB Essential MOdulator). Recent data suggest that the human T-cell leukemia virus type I Tax oncoprotein that activates NF-kB binds neither to IKKa nor IKKb, but complexes directly with IKKg. This suggests that IKKg may be a key molecule acting as an adapter for onco-protein specific signaling to IKKa and IKKb.

Bioinformatics

Entrez	8517 Human
Uniprot	NP_001093326 Human
Product By Gene ID	8517
Alternate Names	FIP-3IP2 FIP3NF-kappa-B essential modifier FIP3P I-kappa-B kinase subunit gamma IkB kinase gamma subunit IkB kinase subunit gamma IkB kinase-associated protein 1 IKBKG IKK gamma IKKAP1 IKKG IKK-gammaIPD2 incontinentia pigmenti inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma Inhibitor of nuclear factor kappa-B kinase subunit gamma IP IP1 NEMO NEMOAMCBX1 NFkappaB essential modulator NF-kappa-B essential modulator

Research Areas for IKK gamma

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Apoptosis
Cancer
Immunology
Innate Immunity

Related IKK gamma Blog Posts

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Regulating Immune Response Pathways with IKK beta IKK beta, also known as IKK2, activates the NFkB complex by phosphorylating the NFkB inhibitor, IkBa. Several transcript variants, some protein-coding and some not, have been found for IKKB. The Nuclear Factor-kappa B (NF-kB) family of transcription f...    Read more.

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