Glut4 Products

Description

The stimulation of glucose uptake by insulin in muscle and adipose tissue requires translocation of the GLUT4 glucose transporter from intracellular storage sites to the cell surface. Activation of phosphatidylinositol-3-OH kinase (PI3K) is required for this trafficking event, but it is not sufficient to produce GLUT4 translocation. Human insulin resistance involves a defect in GLUT4 traffic and targeting leading to accumulation in a dense membrane compartment from which insulin is unable to recruit GLUT4 to the cell surface.

Bioinformatics

Entrez	20528 Mouse 25139 Rat 6517 Human
Uniprot	NP_001033 Human NP_001033.1 Human P14142 Mouse P14672 Human
Product By Gene ID	6517
Alternate Names	GLUT-4 GLUT4Glucose transporter type 4, insulin-responsive insulin-responsive glucose transporter type 4 solute carrier family 2 (facilitated glucose transporter), member 4 solute carrier family 2, facilitated glucose transporter member 4

Research Areas for Glut4

Find related products by research area and learn more about each of the different research areas below.

Diabetes Research
Lipid and Metabolism
Membrane Trafficking and Chaperones

Related Glut4 Blog Posts

Check out the latest blog posts on Glut4.

Glucose Transporter 4 (GLUT4, SLC2A4) GLUT4 is an insulin-sensitive glucose transporter that facilitates insulin-stimulated glucose uptake in adipose tissue, skeletal muscle, and cardiac tissues that specifically express this protein. It is a twelve transmembrane domain multi-pass protein...    Read more.

Read more Glut4 related blogs.