Home » EphB4 Products

We're moving to rndsystems.com. Come with us!

After August 17, 2026, Novus Biologicals products and services will no longer be available on this website; you will access all products and services on rndsystems.com. Create your R&D Systems online account today.

Register on R&D Systems

EphB4 Products

Antibodies
EphB4 Antibody
EphB4 Antibody
AF446
CTS008) and counterstained with hematoxylin (blue). View our protocol for Chromogenic IHC Staining of Frozen Tissue Sections." class="big_lightbox" target="_blank"> Immunohistochemistry EphB4 Antibody
Western Blot EphB4 Antibody
Western Blot EphB4 Antibody
Western Blot EphB4 Antibody
Species: Mu
Applications: WB, Flow, IHC, CyTOF-ready
Host: Goat Polyclonal
Conjugate Catalog # Availability Size Price
Alexa Fluor 350 AF446U-100UG
Alexa Fluor 405 AF446V-100UG
Alexa Fluor 488 AF446G-100UG
Alexa Fluor 532 AF446X-100UG
Alexa Fluor 594 AF446T-100UG
Alexa Fluor 647 AF446R-100UG
Alexa Fluor 700 AF446N-100UG
Alexa Fluor 750 AF446S-100UG
Alexa Fluor Plus 405 AF446AFP405-100UG
Alexa Fluor Plus 488 AF446AFP488-100UG
Alexa Fluor Plus 555 AF446AFP555-100UG
Alexa Fluor Plus 594 AF446AFP594-100UG
Alexa Fluor Plus 647 AF446AFP647-100UG
Alexa Fluor Plus 680 AF446AFP680-100UG
Allophycocyanin AF446A
Biotin BAF446
CoraFluor 1 AF446CL1
DyLight 350 AF446D
DyLight 405 AF446E
DyLight 488 AF446K
DyLight 550 AF446L
DyLight 594 AF446M
DyLight 650 AF446W
DyLight 680 AF446Y
DyLight 755 AF446Z
FITC AF446F
HRP AF446H
Janelia Fluor 525 AF446JF525
Janelia Fluor 549 AF446I
Janelia Fluor 646 AF446J
Janelia Fluor 669 AF446JF669
PE AF446P
PerCP AF446C
mFluor Violet 450 SE AF446MFV450
mFluor Violet 500 SE AF446MFV500
mFluor Violet 610 SE AF446MFV610
Formulation Catalog # Availability Price  
Carrier Free AF446-SP
EphB4 Antibody [Unconjugated] ...
EphB4 Antibody [Unconjugated]
AF3038
HAF017). A specific band was detected for EphB4 at approximately 120 kDa (as indicated). This experiment was conducted under reducing conditions and using Immunoblot Buffer Group 1." class="big_lightbox" target="_blank"> Western Blot EphB4 Antibody [Unconjugated]
AB-108-C, open histogram), followed by Phycoerythrin-conjugated Anti-Goat IgG Secondary Antibody (Catalog # F0107). View our protocol for Staining Membrane-associated Proteins." class="big_lightbox" target="_blank"> Flow Cytometry EphB4 Antibody [Unconjugated]
CTS008) and counterstained with hematoxylin (blue). View our protocol for Chromogenic IHC Staining of Paraffin-embedded Tissue Sections." class="big_lightbox" target="_blank"> Immunohistochemistry EphB4 Antibody [Unconjugated]
HAF109). This experiment was conducted under reducing conditions and using the 12-230 kDa separation system." class="big_lightbox" target="_blank"> Simple Western EphB4 Antibody [Unconjugated]
HAF017). A specific band was detected for EphB4 at approximately 140 kDa (as indicated) in the parental HEK293T cell line, but is not detectable in knockout HEK293T cell line. GAPDH (Catalog # AF5718) is shown as a loading control. This experiment was conducted under reducing conditions and using Immunoblot Buffer Group 1." class="big_lightbox" target="_blank"> Knockout Validated EphB4 Antibody [Unconjugated]
Western Blot EphB4 Antibody [Unconjugated]
Western Blot EphB4 Antibody [Unconjugated]
Western Blot EphB4 Antibody [Unconjugated]
Species: Hu
Applications: WB, Simple Western, Flow, IHC, CyTOF-ready, KO
Host: Goat Polyclonal
Conjugate Catalog # Availability Size Price
Alexa Fluor 350 AF3038U-100UG
Alexa Fluor 405 AF3038V-100UG
Alexa Fluor 488 AF3038G-100UG
Alexa Fluor 532 AF3038X-100UG
Alexa Fluor 594 AF3038T-100UG
Alexa Fluor 647 AF3038R-100UG
Alexa Fluor 700 AF3038N-100UG
Alexa Fluor 750 AF3038S-100UG
Alexa Fluor Plus 405 AF3038AFP405-100UG
Alexa Fluor Plus 488 AF3038AFP488-100UG
Alexa Fluor Plus 555 AF3038AFP555-100UG
Alexa Fluor Plus 594 AF3038AFP594-100UG
Alexa Fluor Plus 647 AF3038AFP647-100UG
Alexa Fluor Plus 680 AF3038AFP680-100UG
Allophycocyanin AF3038A
Biotin BAF3038
CoraFluor 1 AF3038CL1
DyLight 350 AF3038D
DyLight 405 AF3038E
DyLight 488 AF3038K
DyLight 550 AF3038L
DyLight 594 AF3038M
DyLight 650 AF3038W
DyLight 680 AF3038Y
DyLight 755 AF3038Z
FITC AF3038F
HRP AF3038H
Janelia Fluor 525 AF3038JF525
Janelia Fluor 549 AF3038I
Janelia Fluor 646 AF3038J
Janelia Fluor 669 AF3038JF669
PE AF3038P
PerCP AF3038C
mFluor Violet 450 SE AF3038MFV450
mFluor Violet 500 SE AF3038MFV500
mFluor Violet 610 SE AF3038MFV610
Formulation Catalog # Availability Price  
Carrier Free AF3038-SP
EphB4 Antibody (395810) [Unco ...
EphB4 Antibody (395810) [Unconjuga...
MAB3038
MAB005, open histogram), followed by Allophycocyanin-conjugated Anti-Rat IgG F(ab')2Secondary Antibody (Catalog # F0113)." class="big_lightbox" target="_blank"> Flow Cytometry EphB4 Antibody (395810) [Unconjugated]
Species: Hu
Applications: WB, Flow, CyTOF-ready
Host: Rat Monoclonal
Conjugate Catalog # Availability Size Price
Alexa Fluor 350 FAB3038U-100UG
Alexa Fluor 405 FAB3038V-100UG
Alexa Fluor 488 FAB3038G-100UG
Alexa Fluor 532 FAB3038X
Alexa Fluor 594 FAB3038T-100UG
Alexa Fluor 647 FAB3038R-100UG
Alexa Fluor 700 FAB3038N-100UG
Alexa Fluor 750 FAB3038S-100UG
Alexa Fluor Plus 405 FAB3038AFP405-100UG
Alexa Fluor Plus 488 FAB3038AFP488-100UG
Alexa Fluor Plus 555 FAB3038AFP555-100UG
Alexa Fluor Plus 594 FAB3038AFP594-100UG
Alexa Fluor Plus 647 FAB3038AFP647-100UG
Alexa Fluor Plus 680 FAB3038AFP680-100UG
Allophycocyanin/Cy7 FAB3038APCCY7
Biotin FAB3038B
CoraFluor 1 FAB3038CL1
DyLight 350 FAB3038D
DyLight 405 FAB3038E
DyLight 488 FAB3038K
DyLight 550 FAB3038L
DyLight 594 FAB3038M
DyLight 650 FAB3038W
DyLight 680 FAB3038Y
DyLight 755 FAB3038Z
HRP FAB3038H
Janelia Fluor 525 FAB3038JF525
Janelia Fluor 549 FAB3038I
Janelia Fluor 646 FAB3038J
Janelia Fluor 669 FAB3038JF669
PE/Atto594 FAB3038PEATT594
PE/Cy5.5 FAB3038PECY55
PE/Cy7 FAB3038PECY7
Phycoerythrin FAB3038P
mFluor Violet 450 SE FAB3038MFV450
mFluor Violet 500 SE FAB3038MFV500
mFluor Violet 610 SE FAB3038MFV610
Formulation Catalog # Availability Price  
Carrier Free FAB3038N-100UG
Carrier Free FAB3038P
Carrier Free MAB3038-SP
Carrier Free FAB3038V-100UG
Carrier Free FAB3038U-100UG
Carrier Free FAB3038T-100UG
Carrier Free FAB3038S-100UG
Carrier Free FAB3038R-100UG
Carrier Free FAB3038G-100UG
Read More
Read More
Read More
See All EphB4 Products
We have 27 EphB4 Antibodies
ELISA Kits
Human Phospho-EphB4 DuoSet IC ...
Human Phospho-EphB4 DuoSet IC ELIS...
DYC4057-2
Species: Hu
Applications: ELISA
Conjugate Catalog # Availability Size Price
Biotin DYC4057-5
Read More
See All EphB4 Products
We have 1 EphB4 ELISA Kit
Lysates
EphB4 Overexpression Lysate
EphB4 Overexpression Lysate
NBL1-10293
Western Blot EphB4 Overexpression Lysate
Species: Hu
Applications: WB
Read More
See All EphB4 Products
We have 1 EphB4 Lysate
Proteins
Recombinant Mouse EphB4 Fc Ch ...
Recombinant Mouse EphB4 Fc Chimera...
446-B4
Species: Mu
Applications: Binding Activity
Formulation Catalog # Availability Price  
Carrier Free 446-B4-200
Recombinant Human EphB4 Prote ...
Recombinant Human EphB4 Protein, CF
3038-B4
Species: Hu
Applications: Binding Activity
Formulation Catalog # Availability Price  
Carrier Free 3038-B4-100
Recombinant Human EphB4 Fc Ch ...
Recombinant Human EphB4 Fc Chimera...
11307-B4
496-EB) binds with an ED50 of 0.600-7.20 ng/mL." class="big_lightbox" target="_blank"> Binding Activity EphB4 [Unconjugated]
SDS-Page EphB4 [Unconjugated]
Species: Hu
Applications: Bioactivity
Formulation Catalog # Availability Price  
Carrier Free 11307-B4-100
Read More
Read More
Read More
See All EphB4 Products
We have 3 EphB4 Proteins

Description

EphB4, also known as Htk, Myk1, Tyro11, and Mdk2, is a member of the Eph receptor family, which binds of the ephrin ligand family. Two classes of receptors exist, designated A and B, that have an extracellular domain made up of a globular domain, a cysteine-rich domain, and two fibronectin type III domains, followed by the transmembrane region and cytoplasmic region. The cytoplasmic region contains juxtamembrane motif with two tyrosines, which are the major autophosphorylation sites, along with a kinase domain, and a conserved sterile alpha motif (SAM) in the carboxyl terminus, which includes one conserved tyrosine. Ligand recognition and binding leads to activation of intrinsic kinase activity. Only membrane-bound or Fc-clustered ligands have been shown to activate the receptor in vitro. Soluble monomeric ligands can bind the receptor, but do not induce receptor autophosphorylation and activation. The Eph receptors and ephrin ligands display reciprocal expression in vivo. Developing and adult neural tissue express nearly all of the Eph receptors and ephrin ligands.Ephs and ephrins play a significant role in angiogenesis.

Bioinformatics

Entrez
13846
Mouse
2050
Human
Uniprot
AAH52804
Human
AAH52804.1
Human
NM_004444
Human
NP_004435.3
Human
P54760
Human
Product By Gene ID 2050
Alternate Names
  • EC 2.7.10
  • EC 2.7.10.1
  • EPH receptor B4
  • EphB4
  • ephrin type-B receptor 4
  • hepatoma transmembrane kinase
  • HTKephrin receptor EphB4
  • MYK1
  • soluble EPHB4 variant 1
  • soluble EPHB4 variant 2
  • soluble EPHB4 variant 3
  • TYRO11
  • Tyro11
  • Tyrosine-protein kinase receptor HTK
  • Tyrosine-protein kinase TYRO11

Research Areas for EphB4

Find related products by research area and learn more about each of the different research areas below.

Protein Kinase

Related EphB4 Blog Posts

Check out the latest blog posts on EphB4.
Vimentin: Regulating EMT and Cancer
Vimentin, a member of the intermediate filament (IF) family, is a protein responsible for maintaining cellular integrity and reducing damage caused by stress. The vimentin protein is ubiquitously expressed in normal mesenchymal cells, and recent resea...    Read more.
Read more EphB4 related blogs.