Species: Hu, Mu, Rt, Po, Bv, Ca, Ze
Applications: WB, Simple Western, Flow, ICC/IF, IHC
Host: Mouse Monoclonal
Species: Hu, Mu, Rt, Po, Bv, Eq
Applications: WB, ICC/IF, IHC
Host: Chicken Polyclonal
Species: Hu, Mu, Rt, Gp, Po, Bv, Eq, Pm
Applications: WB, ICC/IF, IHC
Host: Rabbit Polyclonal
Species: Hu
Applications: ELISA
Species: Hu
Applications: WB
Species: Hu
Applications: Enzyme Activity
Description
Ubiquitin carboxyl-terminal hydrolase isozyme L1 (UCHL1) is a soluble cytoplasmic protein found in neurons and in cells of the diffuse neuroendocrine system, and their respective tumors. Therefore, UCH-L1 has been widely used as a peripheral nerve fiber marker. UCHL-1 functions as a tissue-specific ubiquitin carboxyl terminal hydrolase isoenzyme involved in the processing of both ubiquitin precursors and ubiquitinated proteins.
UCH L1 is down-regulated in brains from Parkinson disease and Alzheimer disease patients, and certian site specific mutations in the UCHL1 gene can either increase or decrese the risk of Parkinson's and/or Alzheimer's neurodegenerative diseases.
Human UCHL 1 and the closely related UCHL3 protein have one of the most complicated knot structures ever discovered, with five knot crossings. This knot structure is expected to help the protein resist degradation in the proteasome.
Bioinformatics
| Entrez |
Mouse
Mouse
Rat
Rat
Human
|
| Uniprot |
Human
Human
Human
Human
Human
Human
Rat
|
| Product By Gene ID |
7345 |
| Alternate Names |
- EC 3.4.19.12
- EC 6.-
- Neuron cytoplasmic protein 9.5
- PARK5
- PGP 9.5
- PGP9.5
- PGP9.5Uch-L1
- PGP95
- ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
- ubiquitin carboxyl-terminal hydrolase isozyme L1
- ubiquitin C-terminal hydrolase
- Ubiquitin thioesterase L1
- UCHL1
- UCH-L1
|
