UCH-L1/PGP9.5 Products

Antibodies
UCH-L1/PGP9.5 Antibody
UCH-L1/PGP9.5 Antibody
NB300-675
Species: Hu, Mu, Bovine, Equine, Guinea Pig, Primate, Porcine, Rat
Applications: WB, ICC/IF, IHC, IHC-P
Host: Rabbit Polyclonal
UCH-L1/PGP9.5 Antibody
UCH-L1/PGP9.5 Antibody
NB300-676
Species: Hu, Mu, Equine, Primate, Porcine, Rat
Applications: WB, Simple Western, ICC/IF, IHC, IHC-Fr, IHC-P
Host: Rabbit Polyclonal
Lysates
UCH-L1/PGP9.5 Overexpression ...
UCH-L1/PGP9.5 Overexpression Lysat...
NBL1-17575
Applications: WB
UCH-L1/PGP9.5 Overexpression ...
UCH-L1/PGP9.5 Overexpression Lysat...
H00007345-T02
Species: Hu
Applications: WB
Proteins
UCH-L1/PGP9.5 Recombinant Pro ...
UCH-L1/PGP9.5 Recombinant Protein
H00007345-P01
Species: Hu
Applications: WB, ELISA, PA
UCH-L1/PGP9.5 Partial Recombi ...
UCH-L1/PGP9.5 Partial Recombinant ...
H00007345-Q02
Species: Hu
Applications: WB, ELISA, PA
UCH-L1/PGP9.5 Partial Recombi ...
UCH-L1/PGP9.5 Partial Recombinant ...
H00007345-Q01
Species: Hu
Applications: WB, ELISA, PA
RNAi
UCH-L1/PGP9.5 RNAi
UCH-L1/PGP9.5 RNAi
H00007345-R01
Species: Hu
Applications: RNAi, RNAi SP

Description

Ubiquitin carboxyl-terminal hydrolase isozyme L1 (UCHL1) is a soluble cytoplasmic protein found in neurons and in cells of the diffuse neuroendocrine system, and their respective tumors. Therefore, UCH-L1 has been widely used as a peripheral nerve fiber marker. UCHL-1 functions as a tissue-specific ubiquitin carboxyl terminal hydrolase isoenzyme involved in the processing of both ubiquitin precursors and ubiquitinated proteins.

UCH L1 is down-regulated in brains from Parkinson disease and Alzheimer disease patients, and certian site specific mutations in the UCHL1 gene can either increase or decrese the risk of Parkinson's and/or Alzheimer's neurodegenerative diseases.

Human UCHL 1 and the closely related UCHL3 protein have one of the most complicated knot structures ever discovered, with five knot crossings. This knot structure is expected to help the protein resist degradation in the proteasome.

Bioinformatics

Entrez Human
Mouse
Mouse
Rat
Rat
Uniprot Human
Human
Human
Human
Human
Human
Rat
Product By Gene ID 7345
Alternate Names
  • PGP9.5
  • UCHL1
  • UCH-L1
  • EC 6.-
  • PARK5
  • EC 3.4.19.12
  • PGP 9.5
  • ubiquitin carboxyl-terminal hydrolase isozyme L1
  • Ubiquitin thioesterase L1
  • ubiquitin C-terminal hydrolase
  • Neuron cytoplasmic protein 9.5
  • PGP95
  • PGP9.5Uch-L1
  • ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)

Research Areas for UCH-L1/PGP9.5

Find related products by research area and learn more about each of the different research areas below.

Alzheimers Research
Cellular Markers
Neurodegeneration
Neuronal Cell Markers
Neuroscience
Neurotransmission

Bioinformatics Tool for UCH-L1/PGP9.5

Discover related pathways, diseases and genes to UCH-L1/PGP9.5. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
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